56245-07-9

Basic information

• Product Name: (4-Methoxy-3-nitro-phenyl)-acetonitrile
• Synonyms: (4-Methoxy-3-nitro-phenyl)-acetonitrile
• CAS NO: 56245-07-9
• Molecular Formula: C₉H₈N₂O₃
• Molecular Weight: 192.17142
• EINECS: -0
• Mol File: 56245-07-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-Methoxy-3-nitro-phenyl)-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Methoxy-3-nitro-phenyl)-acetonitrile(56245-07-9)
• EPA Substance Registry System: (4-Methoxy-3-nitro-phenyl)-acetonitrile(56245-07-9)

Safety Data

• Hazardous Substances Data: 56245-07-9(Hazardous Substances Data)

Usage

Description

(4-Methoxy-3-nitro-phenyl)-acetonitrile, with the molecular formula C9H8N2O3, is a yellow solid chemical compound. It serves as a crucial intermediate in the synthesis of a wide range of organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. Its versatility in organic synthesis is attributed to its capacity for various chemical reactions, such as nucleophilic substitution and reduction. Furthermore, it has been explored for potential biological activities, including anticancer and antimicrobial properties.

Uses

Used in Pharmaceutical Industry:
(4-Methoxy-3-nitro-phenyl)-acetonitrile is used as a starting material for the synthesis of various pharmaceuticals. Its ability to undergo multiple chemical reactions makes it a valuable building block in the development of new drugs and medications.
Used in Agrochemical Industry:
In the agrochemical sector, (4-Methoxy-3-nitro-phenyl)-acetonitrile is utilized as a precursor in the production of different agrochemicals, contributing to the development of more effective and targeted pest control solutions.
Used in Fine Chemicals Industry:
(4-Methoxy-3-nitro-phenyl)-acetonitrile is also employed as an intermediate in the synthesis of specialty chemicals, which are used in various applications such as fragrances, dyes, and coatings.
Used in Research and Development:
(4-Methoxy-3-nitro-phenyl)-acetonitrile is used as a research tool for investigating its potential biological activities, such as anticancer and antimicrobial properties. The findings from these studies could lead to the development of new therapeutic agents and treatments.
Overall, (4-Methoxy-3-nitro-phenyl)-acetonitrile is an essential chemical intermediate with diverse applications across multiple industries, particularly in the fields of pharmaceuticals and fine chemicals.

Upstream product

• 143-33-9 sodium cyanide 
• 6378-19-4 4-methoxy-3-nitrobenzyl chloride 
• 151-50-8 potassium cyanide 
• 104-47-2 p-methoxybenzylnitrile 
• 61010-34-2 3-nitro-4-methoxybenzyl bromide 
• 13435-20-6 tetraethylammoniumcyanide 
• 119-10-8 4-methoxy-3-nitrotoluene 

Downstream Products

• 725256-16-6 2-(3-amino-4-methoxyphenyl)acetonitrile 
• 63367-09-9 (4-hydroxy-3-nitro-phenyl)-acetic acid amide 
• 857544-00-4 2-(4-methoxy-3-nitrophenyl)acetamide 
• 63304-80-3 (4-methoxy-3-nitrophenyl)acetic acid 
• 908584-11-2 3-(4-methoxy-2-nitrophenyl)-2-(4-methoxy-3-nitrophenyl)propionitrile 
• 34837-88-2 methyl 2-(4-methoxy-3-nitrophenyl)acetate 
• 63304-82-5 (3-amino-4-methoxy-phenyl)-acetic acid methyl ester 
• 400648-58-0 ethyl (3-amino-4-methoxyphenyl)acetate 
• 400648-57-9 4-methoxy-3-nitrophenylacetic acid ethyl ester 
• 1131-94-8 homoisovanillic acid 
• 104967-36-4 (3-mercapto-4-methoxy-phenyl)-acetic acid 
• 63304-81-4 2-(3-amino-4-methoxyphenyl)acetic acid 
• 857544-42-4 [3-(3-carboxy-2-nitro-phenylsulfanyl)-4-methoxy-phenyl]-acetic acid 

Relevant articles and documents

INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND METHODS OF THEIR USE

The present invention provides compounds of formula (I) wherein all of the variables are as defined herein. These compounds are inhibitors of indoleamine 2,3-dioxygenase (IDO), which may be used as medicaments for the treatment of proliferative disorders, such as cancer, viral infections and/or autoimmune diseases.

Role of the benzylic hydroxyl group of adrenergic catecholamines in eliciting α-adrebergic activity. Synthesis and α1- and α2-adrenergic activity of 3-phenyl-3-piperidinols and their desoxy analogs

In order to contribute to the definition of the role played by the benzylic hydroxyl group of adrenergic catecholamines in eliciting α-adrenergic activity, certain 3-phenyl-3-piperidinols (PPOs, 4) and their corresponding desoxy 3-phenylpiperidine analogs (PPEs, 6) were synthesized and tested for their α1- and α2-adrenergic activity by means of functional tests on isolated preparations.As regards the α1-adrenergic activity, the values of the activity indices of the cyclic catecholic compounds (PPO 4a and PPE 6a) indicate that the benzylic hydroxyl does notplay an essential role, provided that the other two active groups are in the pharmacophoric conformation.However, the fact that none of the other non-catecholic cyclic analogs are active on the α1-receptor does not allow us to generalize this observation.As regards the α2-adrenergic activity, the high values of the activity indices of PPEs 6, compared with those of the corresponding 1-phenyl-2-aminoethanols (PAEs,3), PPPOs (4) and 2-phenylethylamines (PEAs,5), confirm that when the aromatic moiety and the amino group are constrained into the pharmacophoric relationship, the presence of the alcoholic hydroxyl is not only unnecessary for the purposes of the expression of the activity at the level of the α2-adrenoceptor, but often has negative effect. adrenergic drug / 3-phenyl-3-piperidinol / 3-phenylpiperidine / 1-phenyl-2-aminoethanol / 2-phenylethylamine / α1-adrenergic agonist activity / α2-adrenergic agonist activity