5625-52-5

Basic information

• Product Name: 1 - Methylpiperazine - 2,5 - dione
• Synonyms: 1 - Methylpiperazine - 2,5 - dione;1-methyl-2,5-Piperazinedione
• CAS NO: 5625-52-5
• Molecular Formula: C₅H₈N₂O₂
• Molecular Weight: 128.12922
• Mol File: 5625-52-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 141-143 °C
• Boiling Point: 427°Cat760mmHg
• Flash Point: 212.1°C
• Appearance: /
• Density: 1.202g/cm³
• Vapor Pressure: 1.69E-07mmHg at 25°C
• Refractive Index: 1.481
• PKA: 13.04±0.20(Predicted)
• CAS DataBase Reference: 1 - Methylpiperazine - 2,5 - dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1 - Methylpiperazine - 2,5 - dione(5625-52-5)
• EPA Substance Registry System: 1 - Methylpiperazine - 2,5 - dione(5625-52-5)

Safety Data

• Hazardous Substances Data: 5625-52-5(Hazardous Substances Data)

Usage

General Description

1-Methylpiperazine-2,5-dione, also known as N-Methylpiperazinedione, is a chemical compound with the molecular formula C6H10N2O2. It is a white crystalline solid that is soluble in water and ethanol. 1 - Methylpiperazine - 2,5 - dione is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized as a building block for the production of various organic compounds. Furthermore, 1-Methylpiperazine-2,5-dione has potential applications in the field of medicinal chemistry for the development of new drugs. Overall, this chemical serves multiple industrial and scientific purposes due to its versatile reactivity and stability.

InChI:InChI=1/C5H8N2O2/c1-7-3-4(8)6-2-5(7)9/h2-3H2,1H3,(H,6,8)

Upstream product

• 29816-01-1 Glycylsarcosine 
• 38082-72-3 sarcosine-glycine 
• 24515-53-5 [(2-chloroacetyl)(methyl)amino]acetic acid ethyl ester 
• 5076-82-4 sarcosine anhydride 
• 174311-10-5 methyl N'-(tert-butoxycarbonyl)glycylsarcosinate 
• 145590-97-2 N-tert-butoxycarbonylglycylsarcosine ethyl ester 
• 65332-01-6 methyl N-(2-chloroacetyl)glycine 

Downstream Products

• 109-01-3 1-methyl-piperazine 
• 59136-05-9 1-benzyl-4-methylpiperazine-2,5-dione 
• 79247-68-0 1-Methoxymethyl-4-methyl-piperazine-2,5-dione 
• 170376-79-1 1-Acetyl-4-methylpiperazine-2,5-dione 
• 562814-60-2 3,6-dihydro-1-methyl-5-methylthiopyrazin-2(1H)-one 
• 562814-58-8 1-methylpiperazin-2,5-dithione 
• 562814-59-9 1-methyl-5-thioxopiperazin-2-one 
• 562814-61-3 1-methyl-5-cyanoiminopiperazin-2-one 
• 155090-89-4 1-benzyl-3,6-dibromo-4-methylpiperazine-2,5-dione 
• 67-99-2 dl-Gliotoxin 
• 1668-07-1 dl-dehydrogliotoxin 
• 79247-63-5 (1R,5R)-6-(2-Hydroxymethyl-6-methoxy-phenyl)-3-(4-methoxy-phenyl)-8-methyl-2,4-dithia-6,8-diaza-bicyclo[3.2.2]nonane-7,9-dione 
• 565433-79-6 2-(2,5-Bis-acetylsulfanyl-4-methyl-3,6-dioxo-piperazin-1-yl)-3-methoxy-benzoic acid methyl ester 

Relevant articles and documents

N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE

The invention relates to compounds of formula (I), or a salt thereof wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ανβ1 integrin inhibitors that are useful for treating tissue specific fibrosis.

[11C]Glycylsarcosine: Synthesis and in vivo evaluation as a PET tracer of PepT2 transporter function in kidney of PepT2 null and wild-type mice

[11C]Glycylsarcosine (Gly-Sar) was synthesized as a potential radiotracer to investigate the localization and in vivo function of the peptide transporter PepT2 in mouse kidney. Its C-11 labeled diketopiperazine derivative, [11C]cyclo(Gly-Sar) [1-methylpiperazine-2,5-dione], was also evaluated as a potential tracer. [11C]Gly-Sar exhibited rapid initial uptake into kidneys with slow clearance from the medulla, consistent with uptake and retention of the radiotracer through the actions of PepT2. In contrast, the corresponding cyclized dipeptide [11C]cyclo(Gly-Sar) showed rapid clearance and accumulation only in the renal pelvis region. Involvement of PepT2 in reabsorption and delayed clearance of [ 11C]Gly-Sar was confirmed using the PepT2 knockout mouse, where rapid renal elimination of [11C]Gly-Sar and the absence of radioactivity in medulla were observed. This study demonstrates using in vivo imaging technique that PepT2 is primarily responsible for renal tubular active reabsorption of Gly-Sar, and provides a new tool for studying tubular peptide reabsorption and clearance.

Active esters of N-substituted piperazine acetic acids, including isotopically enriched versions thereof

In some embodiments, this invention pertains to active esters of N-substituted piperazine acetic acid, including isotopically enriched versions thereof. In some embodiments, this invention pertains to methods for the preparation of active esters of N-subs