5626-52-8

Basic information

• Product Name: 5-OXOPYRROLIDINE-2-CARBOXAMIDE
• Synonyms: 5-OXOPYRROLIDINE-2-CARBOXAMIDE
• CAS NO: 5626-52-8
• Molecular Formula: C₅H₈N₂O₂
• Molecular Weight: 128.13
• Mol File: 5626-52-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 515.9°Cat760mmHg
• Flash Point: 265.8°C
• Appearance: /
• Density: 1.285g/cm³
• Vapor Pressure: 9.45E-11mmHg at 25°C
• Refractive Index: 1.514
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-OXOPYRROLIDINE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-OXOPYRROLIDINE-2-CARBOXAMIDE(5626-52-8)
• EPA Substance Registry System: 5-OXOPYRROLIDINE-2-CARBOXAMIDE(5626-52-8)

Safety Data

• Hazardous Substances Data: 5626-52-8(Hazardous Substances Data)

Usage

General Description

5-OXOPYRROLIDINE-2-CARBOXAMIDE is a chemical compound that belongs to the class of pyrrolidines. It is also known by its IUPAC name, 5-oxo-2-pyrrolidinecarboxamide. 5-OXOPYRROLIDINE-2-CARBOXAMIDE is used in various industrial applications, including as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of polymers and resins. 5-OXOPYRROLIDINE-2-CARBOXAMIDE is known for its high stability and compatibility with other chemicals, making it a versatile and valuable component in many manufacturing processes. However, it is important to handle this compound with care, as it may be hazardous if not properly managed.

InChI:InChI=1/C5H8N2O2/c6-5(9)3-1-2-4(8)7-3/h3H,1-2H2,(H2,6,9)(H,7,8)

Upstream product

• 56-86-0 L-glutamic acid 
• 16450-41-2 L-glutamic acid diethyl ester 
• 55478-53-0 pyroglutamoyl chloride 
• 149-87-1 Pyroglutamic acid 
• 4931-66-2 methyl 5-oxopyrrolidine-2-carboxylate 
• 4344-84-7 5-oxo-tetrahydro-furan-2-carboxylic acid 
• 7664-41-7 ammonia 

Downstream Products

• 617-65-2 Glutamic acid 
• 6893-26-1 D-Glutamic acid 
• 5626-50-6 5-cyano-2-pyrrolidinone 
• 98062-39-6 N-chloroacetylpyroglutamic acid nitrile 
• 106203-75-2 N-phenylacetylpyroglutamic acid nitrile 
• 92503-18-9 ethyl 4,5-diamino-5-oxopentanoate hydrochloride 

Relevant articles and documents

Corresponding amine nitrile and method of manufacturing thereof

The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.

Chemie der α-Aminonitrile. 1. Mitteilung. Einleitung und Wege zu Uroporphyrinogen-octanitrilen

Chemistry of α-Aminonitriles I: Introduction and Pathways to Uroporphyrinogen-octanitriles.An introduction to experimental studies on the chemistry of α-aminonitriles potentially relevant to the problems of prebiotic chemistry is presented.The framework of conditions wherein the investigations is chosen to be carried out implies both molecular oxygen and - whenever feasible - water to be excluded from reaction conditions.This study focusses on 2-amino-2-propenenitrile (3) (Scheme 6) as central starting material of reaction sequences which aim at the nitrile forms of proteinogenic amino acids as well as at the aza forms of building blocks of biological cofactor molecules as their targets (Scheme 5).Schemes 13, 16, 23 as well as 25, and 26 summarize reaction sequences by which 3 is tranformed within the definied framework of conditions into the thermodynamic (statistically controlled) mixture of the four isomeric uroporphyrinogen-octanitriles 57-60.HPLC's of such mixtures document the dominance of the least symmetrical isomer whose constitutional pattern of peripheral substituents happens to be the one present in all biological porphinoids.Preparative procedures for the synthesis of 3 (Scheme 9), the β,β-disubstututed pyrrol-nitriles 30, 53, and 54 (Scheme 19) as well as the porphyrinogen-octakis(propionitrile) and -octakis(acetonitrile) 65 and 66, respectively (Scheme 24) are given.

Synthetic luteinizing hormone-releasing factor analogs. Series of short-chain amide LRF homologs converging to the amino terminus.

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