5628-90-0Relevant articles and documents
Insights into the Mechanism of Thiol-Triggered COS/H2S Release from N-Dithiasuccinoyl Amines
Zhou, Shengchao,Mou, Yujie,Liu, Miao,Du, Qian,Ali, Basharat,Ramprasad, Jurupula,Qiao, Chunhua,Hu, Li-Fang,Ji, Xingyue
, p. 8352 - 8359 (2020/09/07)
The hydrolysis of carbonyl sulfide (COS) to form H2S by carbonic anhydrase has been demonstrated to be a viable strategy to deliver H2S in a biological system. Herein, we describe N-dithiasuccinoyl amines as thiol-triggered COS/H2S donors. Notably, thiol species especially GSH and homocysteine can trigger the release of both COS and H2S directly from several specific analogues via an unexpected mechanism. Importantly, two representative analogues Dts-1 and Dts-5 show intracellular H2S release, and Dts-1 imparts potent anti-inflammatory effects in LPS-challenged microglia cells. In conclusion, N-dithiasuccinoyl amine could serve as promising COS/H2S donors for either H2S biological studies or H2S-based therapeutics development.
Catalysis by μ-Oxo Diiron(III) Complexes of the Methanolysis of Epoxides and the Addition of Alcohols and Thiols to Phenyl Isocyanate
Houghton, Roy P.,Rice, Craig R.
, p. 2265 - 2266 (2007/10/02)
Carboxylate-bridged μ-oxo diiron(III) complexes of the type 1 very efficiently catalyse (a) the addition of alcohols and thiols to phenyl isocyanate and (b) the ring-opening of epoxides by methanol, with their efficiency being dependent upon the size of the group R.