56291-51-1

Basic information

• Product Name: N3-Methylpyridine-2,3-diamine
• Synonyms: N3-Methylpyridine-2,3-diamine;2-Amino-3-methylaminopyridine
• CAS NO: 56291-51-1
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.158
• Mol File: 56291-51-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 178-179℃
• Boiling Point: 138℃ (1 Torr)
• Flash Point: 122.913°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: 2-8°C
• PKA: 7.10±0.36(Predicted)
• CAS DataBase Reference: N3-Methylpyridine-2,3-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N3-Methylpyridine-2,3-diamine(56291-51-1)
• EPA Substance Registry System: N3-Methylpyridine-2,3-diamine(56291-51-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 56291-51-1(Hazardous Substances Data)

Usage

General Description

N3-Methylpyridine-2,3-diamine is an organic compound with the chemical formula C7H10N4. It is also known as 2,3-Diamino-3-methylpyridine and is commonly used in the production of pharmaceuticals, dyes, and other organic compounds. This chemical is a member of the pyridine family, which is characterized by a six-membered ring containing five carbon atoms and one nitrogen atom. N3-Methylpyridine-2,3-diamine is a colorless to pale yellow liquid with a strong odor, and it is considered to be hazardous if ingested, inhaled, or absorbed through the skin. It is important to handle this chemical with care and according to safety guidelines to prevent any potential health risks.

InChI:InChI=1/C6H9N3/c1-8-5-3-2-4-9-6(5)7/h2-4,8H,1H3,(H2,7,9)

Upstream product

• 18364-47-1 N-methyl-N-(3-pyridyl)amine 
• 40932-43-2 (2-chloro-pyridin-3-yl)-methyl-amine 
• 32605-06-4 3-(N-methylamino)-2-nitropyridine 
• 98961-03-6 (2-amino-[3]pyridyl)-methyl-carbamic acid ethyl ester 
• 99314-92-8 N²-amino-N³-benzyloxycarbonylaminopyridine 
• 452-58-4 2,3-Diaminopyridine 
• 20265-37-6 3-methoxy-2-nitropyridine 
• 54231-32-2 3-chloro-2-nitropyridine 
• 1353677-72-1 N-benzyl-N-methyl-2-nitropyridin-3-amine 
• 54231-35-5 3-fuoro-2-nitropyridine 
• 13269-19-7 3-amino-2-nitropyridine 
• 13534-99-1 2-Amino-3-bromopyridine 
• 74-89-5 methylamine 

Downstream Products

• 1471-84-7 1-methyl-2-oxo-1,2-dihydro-pyrido[2,3-b]pyrazine-3-carboxylic acid ethyl ester 
• 50339-06-5 1-methyl-1,3-dihydro-2H-imidazo<4,5-b>pyridin-2-one 
• 103432-67-3 1-methyl-3-t-butoxycarbonyl-1,3-dihydro-2H-imidazo<4,5-b>pyridin-2-one 
• 133466-07-6 (E)-2-(1-Methyl-1H-imidazo[4,5-b]pyridin-2-yl)-3-phenyl-acrylonitrile 
• 133466-03-2 (Z)-2-(1-Methyl-1H-imidazo[4,5-b]pyridin-2-yl)-3-phenyl-thioacrylamide 
• 133466-09-8 (E)-3-(4-Hydroxy-3-methoxy-phenyl)-2-(1-methyl-1H-imidazo[4,5-b]pyridin-2-yl)-acrylonitrile 
• 133466-10-1 (E)-3-(4-Diethylamino-phenyl)-2-(1-methyl-1H-imidazo[4,5-b]pyridin-2-yl)-acrylonitrile 
• 133466-01-0 (Z)-3-(4-Hydroxy-3-methoxy-phenyl)-2-(1-methyl-1H-imidazo[4,5-b]pyridin-2-yl)-thioacrylamide 
• 133466-08-7 (E)-3-(3,4-Dimethoxy-phenyl)-2-(1-methyl-1H-imidazo[4,5-b]pyridin-2-yl)-acrylonitrile 
• 133466-02-1 (Z)-3-(4-Diethylamino-phenyl)-2-(1-methyl-1H-imidazo[4,5-b]pyridin-2-yl)-thioacrylamide 
• 133466-00-9 (Z)-3-(3,4-Dimethoxy-phenyl)-2-(1-methyl-1H-imidazo[4,5-b]pyridin-2-yl)-thioacrylamide 
• 133465-98-2 (1-Methyl-1H-imidazo[4,5-b]pyridin-2-yl)-acetic acid [1-(4-hydroxy-3-methoxy-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 133465-97-1 (1-Methyl-1H-imidazo[4,5-b]pyridin-2-yl)-acetic acid [1-(3,4-dimethoxy-phenyl)-meth-(Z)-ylidene]-hydrazide 
• 80708-25-4 4-methyl-1,4-dihydropyrido[2,3-b]piperazine-2,3-dione 

Relevant articles and documents

C2-Selective Branched Alkylation of Benzimidazoles by Rhodium(I)-Catalyzed C-H Activation

Herein, we report a Rh(I)/bisphosphine/K3PO4 catalytic system allowing for the first time the selective branched C-H alkylation of benzimidazoles with Michael acceptors. Branched alkylation with N,N-dimethyl acrylamide was successfully applied to the alkylation of a broad range of benzimidazoles incorporating a variety of N-substituents and with both electron-rich and -poor functionality displayed at different sites of the arene. Moreover, the introduction of a quaternary carbon was achieved by alkylation with ethyl methacrylate. The method was also shown to be applicable to the C2-selective branched alkylation of azabenzimidazoles.

Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase

In order to explore the interactions of bisphosphonate ligands with the active site and an allosteric pocket of the human farnesyl pyrophosphate synthase (hFPPS), substituted indole and azabenzimidazole bisphosphonates were designed as chameleon ligands. NMR and crystallographic studies revealed that these compounds can occupy both sub-pockets of the active site cavity, as well as the allosteric pocket of hFPPS in the presence of the enzyme's Mg2+ ion cofactor. These results are consistent with the previously proposed hypothesis that the allosteric pocket of hFPPS, located near the active site, plays a feed-back regulatory role for this enzyme.

Efficient synthesis of substituted imidazo[4,5-b] pyridine

An efficient approach to the synthesis of 1-methylimidazo[4,5-b]pyridine derivatives 5-10 of biological interest has been developed. The key intermediate product 4 is obtained by cyclization of 2-amino-3-methylaminopyridine (3) with phenylacetic acid.