563-24-6Relevant articles and documents
Preparation method of glycerophosphocholine
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Paragraph 0028-0032; 0033-0037; 0038-0042; 0043-0047, (2021/09/08)
The invention discloses a preparation method of glycerophosphocholine, which comprises the following steps: 1, dissolving lecithin in an alcohol solvent, then adding inorganic base or organic base for hydrolysis reaction to obtain a reaction solution, filtering, adding acid into the filtrate to adjust the pH value, and drying the alcohol solvent by distillation under reduced pressure to obtain a compound (I); 2, dissolving the compound (I) in water, and adding an extraction solvent for extraction to obtain a compound (II); and 3, carrying out active carbon decoloration on the compound (II) through a water phase, directly stirring by using mixed anion-cation resin, drying by distillation, and adding a recrystallization solvent to carry out recrystallization reaction to obtain refined glycerophosphocholine. According to the invention, lecithin is hydrolyzed in an alcohol solvent by using an inorganic weak base through a chemical hydrolysis method, and glycerophosphocholine which is very high in purity and reaches a medicinal level is obtained through a series of simple post-treatment processes, and the production process is simple, easy to control, low in material cost and suitable for industrial production of glycerophosphocholine.
Synthesis method for compound choline alfoscerate for promoting brain functions
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Paragraph 0023-0024; 0026-0028, (2019/11/21)
The invention discloses a synthesis method for a compound choline alfoscerate for promoting brain functions. The synthesis method comprises the following steps: (1) enabling calcium phosphorylcholinechloride to react with oxalic acid to generate precipitate of phosphorylcholine chloride and oxalic acid; (2) enabling the phosphorylcholine chloride prepared in the step (1) to react with an alkali in a solvent so as to obtain a salt of the phosphorylcholine chloride; and (3) enabling the salt of the phosphorylcholine chloride to react with propylene glycol, so as to obtain choline alfoscerate. Raw materials of the synthesis method for the compound choline alfoscerate for promoting brain functions are low in price, low in cost and easy to obtain, the synthesis method is short in synthesis path and high in yield, the obtained product is high in chemical purity, all reactions need no special production equipment, the obtained intermediate and final products need no column chromatography orcrystallization purification, the production cost can be lowered, industrial amplified production can be facilitated, a high-purity product can be provided for the market, and thus high economic benefits can be met.
Glycerin phosphatidyl choline preparation method
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Paragraph 0030; 0063; 0064; 0065; 0066, (2018/04/20)
The invention discloses a preparation method of glycerinum phosphatidylcholine. The preparation method comprises the following steps: (1) mixing a compound shown in formula (I) and anhydrous sodium carbonate to obtain a mixture M1; (2) placing the mixture M1 and (R)-(-)-3-chlorine-1,2-propanediol in anhydrous ethanol, and carrying out the refluxing to obtain a mixture M2; (3) filtering the mixture M2, carrying out the membrane separation, removing sodium chloride in the mixture M2, and obtaining filter liquid M3; (4) adding zinc chloride into the filter liquid M3, and dissolving the zinc chloride by adding water to obtain a mixture M4; (5) enabling the mixture M4 to flow by ion exchange resin, filtering the mixture M4, obtaining the filter liquid, and preparing the glycerinum phosphatidylcholine; (see the specifications), wherein R is Ca or Mg. By adopting the method, the glycerinum phosphatidylcholine is simple to prepare, and the yield is high, so that an effect of simple preparation method, high synthesis rate and low production cost can be realized.
