5631-83-4

Basic information

• Product Name: 3-ETHYLPENTANENITRILE
• Synonyms: 3-ETHYLPENTANENITRILE
• CAS NO: 5631-83-4
• Molecular Formula: C₇H₁₃N
• Molecular Weight: 111.18482
• Mol File: 5631-83-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-ETHYLPENTANENITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ETHYLPENTANENITRILE(5631-83-4)
• EPA Substance Registry System: 3-ETHYLPENTANENITRILE(5631-83-4)

Safety Data

• Hazardous Substances Data: 5631-83-4(Hazardous Substances Data)

Upstream product

• 143-33-9 sodium cyanide 
• 3814-34-4 2-ethyl-1-bromobutane 
• 372-09-8 cyanoacetic acid 
• 96-22-0 pentan-3-one 
• 4737-41-1 3-(chloromethyl)pentane 
• 646-04-8 (E)-pent-2-ene 
• 75-05-8 acetonitrile 
• 151-50-8 potassium cyanide 
• 97-95-0 2-ethyl-1-butanol 
• 51116-73-5 3-methylpentyl bromide 
• 773837-37-9 sodium cyanide 

Relevant articles and documents

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Structure-activity relationships of pregabalin and analogues that target the α2-δ protein

Pregabalin exhibits robust activity in preclinical assays indicative of potential antiepileptic, anxiolytic, and antihyperalgesic clinical efficacy. It binds with high affinity to the α2-δ subunit of voltage-gated calcium channels and is a substrate of the system L neutral amino acid transporter. A series of pregabalin analogues were prepared and evaluated for their α2-δ binding affinity as demonstrated by their ability to inhibit binding of [3H]gabapentin to pig brain membranes and for their potency to inhibit the uptake of [3H]leucine into CHO cells, a measure of their ability to compete with the endogenous substrate at the system L transporter. Compounds were also assessed in vivo for their ability to promote anxiolytic, analgesic, and anticonvulsant actions. These studies suggest that distinct structure activity relationships exist for α2-δ binding and system L transport inhibition. However, both interactions appear to play an important role in the in vivo profile of these compounds.

Pyrazolo-[1,5-a]-1,3,5-triazine corticotropin-releasing factor (CRF) receptor ligands

The syntheses and rat CRF receptor binding affinities of 'retro-pyrazolotriazine' corticotropin-releasing factor (CRF) ligands 4 are reported. Some have high affinity for rat CRF receptors (Ki≤10 nM). The data provide additional support for the hypothesis that it is possible to interchange isosteric cores with similar electronic properties in the design of high-affinity CRF receptor ligands, provided the peripheral pharmacophore elements are maintained in the same three-dimensional array.