5632-36-0

Basic information

• Product Name: 4(1H)-Quinazolinone,2,3-dihydro-
• Synonyms: 2,3-dihydroquinazolin-4(1H)-one;2,3-Dihydro-1H-quinazolin-4-one;4-Oxo-1,2,3,4-tetrahydro-chinazolin;3H-quinazolinyl-4-one;1,2,3,4-tetrahydroquinazolin-4-one;2,3-Dihydro-1H-chinazolin-4-on
• CAS NO: 5632-36-0
• Molecular Formula: C8H8N2O
• Molecular Weight: 148.164
• Mol File: 5632-36-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4(1H)-Quinazolinone,2,3-dihydro- (CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-Quinazolinone,2,3-dihydro- (5632-36-0)
• EPA Substance Registry System: 4(1H)-Quinazolinone,2,3-dihydro- (5632-36-0)

Safety Data

• Hazardous Substances Data: 5632-36-0(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 28144-70-9 anthranilic acid amide 

Downstream Products

• 16347-56-1 3-(prop-2-yn-1-yl)quinazolin-4(3H)-one 
• 5388-11-4 3-benzyl-3H-quinazolin-4-one 
• 491-36-1 4-Hydroxyquinazoline 
• 1415460-77-3 3-(2-iodobenzyl)-2,3-dihydroquinazoline-4(1H)-one 
• 1415460-60-4 1-(2-iodobenzyl)-2,3-dihydroquinazolin-4(1H)-one 
• 1415460-67-1 3-(3-benzyl-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)propanenitrile 
• 1415460-66-0 methyl 3-(3-benzyl-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate 
• 1415460-64-8 tert-butyl 3-(1-benzyl-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate 
• 1415460-63-7 3-(1-benzyl-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)propanenitrile 
• 1415460-61-5 methyl 3-(1-benzyl-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate 
• 1415460-62-6 4-benzyl-2,3,3a,4-tetrahydropyrrolo[2,1-b]quinazoline-1,9-dione 
• 1415460-86-4 (E)-ethyl 6-(1-(2-iodobenzyl)-4-oxo-1,2-dihydroquinazolin-3(4H)-yl)hex-2-enoate 
• 1415460-68-2 tert-butyl 3-(3-benzyl-4-oxo-1,2,3,4-tetrahydroquinazolin-2-yl)propanoate 

Relevant articles and documents

The novel acid-base magnetic recyclable catalyst prepared through carbon disulfide trapping process: Applied for green, one-pot, and efficient synthesis of 2,3-dihydroquinazolin-4 (1H) -ones and bis(indolyl)methanes in large-scale

Herein, a nano acid-base catalyst using magnetic core and carbamodithioic acid functional group have been synthesized and characterized. Its efficiency in the synthesis of dihydroquinazolinones and bis(indolyl)methanes derivatives was investigated. This novel metal-free catalyst exhibited significant catalytic activity in both reactions under green and mild reaction conditions (the yield obtained for the first reaction products: 82–98 % and for the second one: 61–97 %). The catalyst displayed good recyclability with no significant loss of catalytic activity after eight runs (the conversion of the eighth run was found as 83 %, the fresh catalyst conversion was 95 %). The introduced approach is attractive due to its applicability in the large-scale synthesis of important medicinal compounds.

Amino acid catalyzed synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives

A simple, convenient and facile approach for the synthesis of a series of 2,3-dihydroquinazolin-4(1H)-ones in an environmentally benign method has been developed. This method involves a direct cyclocondensation of 2-aminobenzamide with aromatic aldehydes and ketones using aspartic acid as a catalyst in water.

One-Pot Synthesis of Quinazolin-4(3H)-ones through Anodic Oxidation and the Related Mechanistic Studies

A metal-free and oxidant-free method for the one-pot preparation of quinazolin-4(3H)-ones enabled by electrochemical oxidation is described. Together with 2-aminobenzamides, a variety of aldehydes were successfully applied to an acid-catalyzed annulation and direct anodic oxidation cascade, affording structurally diverse quinazoline-4(3H)-ones in good to excellent yields. Additionally, certain alcohols can be directly applied instead of the corresponding aldehydes to achieve the same final products with the assistance of an electrolysis mediator (TEMPO). The reaction mechanism was carefully examined and the results strongly suggest that the direct and indirect oxidation go through different pathways. As an efficient and environmentally friendly access to a broad range of quinazolin-4(3H)-ones, the synthetic utility of this method was demonstrated by gram-scale operation, as well as the preparation of bioactive mackinazolinone and truncated erlotinib. (Figure presented.).