5632-84-8

Basic information

• Product Name: Nortropan-3-one
• Synonyms: nortropan-3-one;(1R,5S)-8-AZABICYCLO[3.2.1]OCTAN-3-ONE;8-Azabicyclo[3.2.1]octan-3-one;3,6-Epiminocycloheptane-1-one;Nortropan-3-on;Nsc351100
• CAS NO: 5632-84-8
• Molecular Formula: C₇H₁₁NO
• Molecular Weight: 125.17
• Product Categories: Heterocycle;Fused Ring Systems
• Mol File: 5632-84-8.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 221.4 °C at 760 mmHg
• Flash Point: 104.3 °C
• Appearance: /
• Density: 1.083 g/cm³
• Vapor Pressure: 1.36E-10mmHg at 25°C
• Refractive Index: 1.572
• PKA: 9.15±0.20(Predicted)
• CAS DataBase Reference: Nortropan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: Nortropan-3-one(5632-84-8)
• EPA Substance Registry System: Nortropan-3-one(5632-84-8)

Safety Data

• Hazardous Substances Data: 5632-84-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 30, p. 3977, 1989 DOI: 10.1016/S0040-4039(00)99299-2

InChI:InChI=1/C24H27NO2/c1-2-3-4-18-5-11-22(12-6-18)24(26)27-23-15-13-21(14-16-23)20-9-7-19(17-25)8-10-20/h7-10,13-16,18,22H,2-6,11-12H2,1H3

Upstream product

• 53912-86-0 2,2,2-trichlorocarboxynortropinone 
• 532-24-1 tropinone 
• 16641-72-8 8-(phenyloxycarbonyl)-8-azabicyclo<3.2.1>octan-3-one 
• 32499-64-2 N-carbethoxytropinone 
• 28957-72-4 N-benzyltropinone 
• 25602-68-0 3-oxo-8-azabicyclo[3.2.1]octane hydrochloride 
• 799283-74-2 1-chloroethyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 185099-67-6 Boc-tropinone 
• 7432-11-3 8-azabicyclo[3.2.1]octan-3-ol 
• 542-05-2 acetonedicarboxylic acid 
• 83393-23-1 N-8-benzyl[3.2.1]8-azabicyclooctan-3-one hydrochloride 
• 478837-18-2 3-exo-hydroxy-8-azabicyclo[3.2.1]octane-8carboxylic acid tert-butyl ester 
• 532-24-1 tropinone 
• 185099-67-6 N-Boc-nortropinone 

Downstream Products

• 496801-85-5 3exo-hydroxy-nortropane-3endo-carbonitrile 
• 18717-73-2 (1R,3r,5S)-8-benzyl-8-azabicyclo[3.2.1]octan-3-ol 
• 780009-57-6 1-aza-4-oxo-1-(4-phenylbutyl)bicyclo<3.2.1>octane 
• 176910-42-2 N-trifluoroacetylnortropinone 
• 185099-67-6 Boc-tropinone 
• 56880-02-5 8-acetyl-8-azabicyclo[3.2.1 ]octan-3-one 
• 28957-72-4 N-benzyltropinone 
• 912641-16-8 3-(3,4-dichloro-phenyl)-8-aza-bicyclo[3.2.1]oct-2-ene 
• 863394-54-1 (1R,3R,5S)-3-(3,4-Dichloro-phenyl)-3-hydroxy-8-aza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester 

Relevant articles and documents

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CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE

The present invention provides novel compounds having the general formula (I) wherein R1 to R6, and m are as described herein, compositions including the compounds and methods of using the compounds.

Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer

After a high-throughput screening campaign identified thioether 1 as an antagonist of the nuclear androgen receptor, a zone model was developed for structure-activity relationship (SAR) purposes and analogues were synthesized and evaluated in a cell-based luciferase assay. A novel thioether isostere, cyclopropane (1S,2R)-27, showed the desired increased potency and structural properties (stereospecific SAR response, absence of a readily oxidized sulfur atom, low molecular weight, reduced number of flexible bonds and polar surface area, and drug-likeness score) in the prostate-specific antigen luciferase assay in C4-2-PSA-rl cells to qualify as a new lead structure for prostate cancer drug development.