5633-55-6

Basic information

• Product Name: 4-PHENYLTHIOPHENOL
• Synonyms: 4-PHENYLTHIOPHENOL;4-Hydroxyphenyl phenyl sulfide;p-(Phenylthio))phenol;Phenyl 4-hydroxyphenyl sulfide;p-Phenylthiophenol
• CAS NO: 5633-55-6
• Molecular Formula: C₁₂H₁₀OS
• Molecular Weight: 186.27
• Mol File: 5633-55-6.mol
• Article Data: 35

Chemical Properties

• Melting Point: 108-110°C
• Boiling Point: 133°C/0.1mm
• Appearance: /
• Density: 1.250
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-PHENYLTHIOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYLTHIOPHENOL(5633-55-6)
• EPA Substance Registry System: 4-PHENYLTHIOPHENOL(5633-55-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 5633-55-6(Hazardous Substances Data)

Usage

General Description

4-Phenylthiophenol is a chemical compound with the molecular formula C12H10S. It is a thiophenol derivative, comprised of a phenyl group attached to a thiophenol ring. 4-Phenylthiophenol is commonly used as a building block in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and materials. It exhibits strong antioxidant and antibacterial properties, making it potentially useful in a range of industrial and medical applications. Additionally, 4-phenylthiophenol is known for its ability to undergo various chemical reactions, such as oxidation, reduction, and substitution, allowing for the facile synthesis of diverse organic molecules.

Upstream product

• 1135-14-4 4-aminophenyl phenyl sulfide 
• 5633-57-8 1-methoxy-4-(phenylsulfanyl)benzene 
• 1192-40-1 copper(I) thiophenolate 
• 106-48-9 4-chloro-phenol 
• 618-41-7 Benzenesulfinic acid 
• 108-95-2 phenol 
• 60-29-7 diethyl ether 
• 931-59-9 benzenesulfenyl chloride 
• 13086-77-6 benzenesulfinic anhydride 
• 100-66-3 methoxybenzene 
• 106-41-2 4-bromo-phenol 
• 108-98-5 thiophenol 
• 10035-10-6 hydrogen bromide 
• 108-24-7 acetic anhydride 

Downstream Products

• 14763-63-4 4-benzenesulfinyl-phenol 
• 111501-42-9 (2-dimethylcarbamoyloxy-5-phenylsulfanyl-benzyl)-trimethyl-ammonium; bromide 
• 5633-57-8 1-methoxy-4-(phenylsulfanyl)benzene 
• 445283-57-8 4-phenylsulfanylphenoxyethyl tetrahydro-2H-pyran-2-yl ether 
• 445283-59-0 4-phenylsulfinylphenoxyethanol 
• 445283-58-9 2-[2-(4-benzenesulfinyl-phenoxy)-ethoxy]-tetrahydro-pyran 
• 445283-60-3 4-phenylsulfinylphenoxyethyl 4-toluenesulfonate 
• 65962-17-6 4-(phenylthio)phenoxyethanol 
• 7402-69-9 p-hydroxyphenyl p-tolyl sulfone 
• 3112-84-3 4-methoxyphenyl phenyl sulfone 
• 882-33-7 diphenyldisulfane 
• 931-59-9 benzenesulfenyl chloride 
• 60677-93-2 propargyloxy-[4-(phenylmercapto)-phenoxy]-methane 

Relevant articles and documents

N-bromosuccinimide/HCl mediated reduction of sulfoxides to sulfides

An efficient reduction of sulfoxides to sulfides mediated by N-bromosuccinimide (NBS)/HCl system has been developed. This protocol shows good functional group compatibility as well as broad substrates scope with operational simplicity.

Microwave-Assisted Copper Slag-Catalyzed Green S-Arylation of Arenethiols with Arylboronic Acids

Abstract: Diaryl sulfides have been synthesized in moderate to excellent yield by S-arylation of arenethiols with arylboronic acids using copper slag as a catalyst. Copper slag is a by-product obtained from smelting and refining of copper. Conventional heating method has been compared with the microwave-assisted technique. The proposed microwave-assisted synthesis provides excellent yields of diaryl sulfides in a short time (10 min) and is ligand-free, green, and cost-effective.

Achieving Nickel Catalyzed C-S Cross-Coupling under Mild Conditions Using Metal-Ligand Cooperativity

A simple and efficient approach of C-S cross-coupling of a wide variety of (hetero)aryl thiols and (hetero)aryl halides under mild conditions, mostly at room temperature, catalyzed by well-defined singlet diradical Ni(II) catalysts bearing redox noninnocent ligands is reported. Taking advantage of ligand centered redox events, the high-energetic Ni(0)/Ni(II) or Ni(I)/Ni(III) redox steps were avoided in the catalytic cycle. The cooperative participation of both nickel and the coordinated ligands during oxidative addition/reductive elimination steps allowed us to perform the catalytic reactions under mild conditions.