5634-37-7

Basic information

• Product Name: Cloretate
• Synonyms: Cloretate;Clorethate;CHLORETHATE;Cloretat;SK&F 12866;SKF-12866;bis(2,2,2-trichloroethyl) carbonate;carbonic acid bis(2,2,2-trichloroethyl) ester
• CAS NO: 5634-37-7
• Molecular Formula: C₅H₄Cl₆O₃
• Molecular Weight: 324.802
• Mol File: 5634-37-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 331.4°Cat760mmHg
• Flash Point: 135.9°C
• Appearance: /
• Density: 1.715g/cm³
• Vapor Pressure: 0.000156mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: Cloretate(CAS DataBase Reference)
• NIST Chemistry Reference: Cloretate(5634-37-7)
• EPA Substance Registry System: Cloretate(5634-37-7)

Safety Data

• Hazardous Substances Data: 5634-37-7(Hazardous Substances Data)

Usage

Uses

Sedative-hypnotic.

InChI:InChI=1/C5H4Cl6O3/c6-4(7,8)1-13-3(12)14-2-5(9,10)11/h1-2H2

Upstream product

• 65-85-0 benzoic acid 
• 17341-93-4 2,2,2-Trichloroethyl chloroformate 
• 117-34-0 2,2-diphenylacetic acid 
• 3006-19-7 9,10-dihydrolysergic acid methyl ester 

Downstream Products

• 159689-43-7 4-(pentafluoro-λ⁶-sulfanyl)phenyl isocyanate 

Relevant articles and documents

A DMAP-catalyzed approach to the industrial-scale preparation of N -6-demethylated 9,10-dihydrolysergic acid methyl ester: A key cabergoline and pergolide precursor

A scalable new approach for the preparation of N-6-demethylated 9,10-dihydrolysergic acid methyl ester using 2,2,2-trichloroethyl chloroformate was developed. A key discovery that enabled the efficient and industrial-scalable process is linked to the rigorous extrusion of water in the reaction system and application of an organic catalyst such as 4-(N,N-dimethylamino)pyridine (DMAP) instead of the alkali metal bicarbonate additives. Namely, in the previously known process, the concomitant presence of bicarbonates and traces of water triggers side reaction cycles that produce and accumulate hydrochloric acid and water. The former slows down the reaction. Moreover, these cycles cause the formation of multiple carbonate and alcohol-type side products to a significant extent that provide a low-quality N-6-demethylated product. All of these shortcomings are circumvented by the application of DMAP as a catalyst and the use of a reaction medium free of water. This approach allows operation on an industrial scale (51 kg batch) with higher yields, shorter reaction times, and improved product quality.

A Simple and Mild Esterification Method for Carboxylic Acids Using Mixed Carboxylic-Carbonic Anhydrides

A simple and mild esterification method using mixed carboxylic-carbonic anhydrides has been developed.Simple aliphatic carboxylic esters are prepared in high yields by the reaction of acids with equimolar amounts of chloroformates (2,2,2-trichloroethyl chloroformate is an exception) and triethylamine in the presence of a catalytic amount of 4-(dimethylamino)pyridine.Although aromatic acids give a mixture of the ester, the acid anhydride, and the carbonate under normal conditions utilized in this study, it is found that increasing the amount of 4-(dimethylamino)pyridine drastically decreases the formation of the acid anhydride and the carbonate, affording a satisfactory yield of the ester.This method reaches a limit with sterically hindered acids and the formation of the acid anhydride and the carbonate is favored.