56352-93-3

Basic information

• Product Name: Pyridine, 3-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-
• CAS NO: 56352-93-3
• Molecular Formula: C14H11N3O2
• Molecular Weight: 253.26
• Mol File: 56352-93-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Pyridine, 3-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 3-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-(56352-93-3)
• EPA Substance Registry System: Pyridine, 3-[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-(56352-93-3)

Safety Data

• Hazardous Substances Data: 56352-93-3(Hazardous Substances Data)

Upstream product

• 614-18-6 3-pyridinecarboxylic acid ethyl ester 
• 553-53-7 Nicotinic acid hydrazide 
• 100-09-4 4-methoxybenzoic acid 
• 100867-76-3 (E)-N'-(4-methoxybenzylidene)pyridine-3-carbohydrazide 
• 56352-80-8 N'-(4-methoxybenzoyl)nicotinohydrazide 

Downstream Products

• 1268376-07-3 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-6-bromo-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 
• 1268376-13-1 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-4-nitro-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 
• 1268376-14-2 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-5,6-dichloro-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 
• 1268376-09-5 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-6-methyl-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 
• 1268376-12-0 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-4-methyl-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 
• 1268376-10-8 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-6-methoxy-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 
• 1268376-08-4 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-6-nitro-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 
• 1268376-06-2 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-6-fluoro-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 
• 1268376-11-9 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-6-chloro-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 
• 1268376-15-3 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-4-chloro-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole 

Relevant articles and documents

Metal-Free Synthesis of 1,3,4-Oxadiazoles from N′-(Arylmethyl)hydrazides or 1-(Arylmethyl)-2-(arylmethylene)hydrazines

An efficient and versatile metal-free synthesis of 1,3,4-oxadiazoles from N′-(arylmethyl)hydrazides or 1-(arylmethyl)-2-(arylmethylene)hydrazines through oxidative dehydrogenation is reported. A range of 2,5-disubstituted 1,3,4-oxadiazoles were prepared by treating N′-(arylmethyl)hydrazides with (diacetoxyiodo)benzene in acetonitrile or by treating 1-(arylmethyl)-2-(arylmethylene)hydrazines with [bis(trifluoroacetoxy)iodo]benzene in methyl tert-butyl ether. Aldehyde N-acylhydrazones and aldazines were initially generated in situ as intermediates.

Antimycobacterial and antimicrobial study of new 1,2,4-triazoles with benzothiazoles

In this study, we report the antimycobacterial and antimicrobial evaluation of newly synthesized 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-substituted-1,3- benzothiazol-2-amino)-4H-1,2,4-triazole 6a-j in good yields. All the synthesized compounds have been established by elemental analysis, IR, 1H NMR, 13C-NMR and Mass spectral data. In-vitro antimycobacterial activity was carried out against (Mycobacterium tuberculosis) H37Rv strain using Lowenstein-Jensen medium and antimicrobial activity against two Gram positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), two Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and three fungal species (Candida albicans, Aspergillus niger, Aspergillus clavatus) using the broth microdilution method. Compounds 2e, 6a, 6g, 6h, and 6j exhibited promising antimicrobial activity whereas compound 6j showed very good antimycobacterial activity. The antimycobacterial and antimicrobial evaluation of newly synthesized 3-(3-pyridyl)-5-(4-methoxyphenyl)-4-(N-substituted-1,3-benzothiazol- 2-amino)-4H-1,2,4-triazoles is reported in detail. Compounds 2e, 6a, 6g, 6h, and 6j exhibited promising antimicrobial activity whereas compound 6j showed very good antimycobacterial activity. Copyright

Oxidative cyclization of aromatic aldehyde n-acylhydrazones by bis(trifluoroacetoxy)iodobenzene

Aromatic aldehyde N-acylhydrazones were oxidized into 2,5-disubstituted 1,3,4-oxadiazoles with bis(trifluoroacetoxy)iodobenzene in CHCl3 or DMSO at room temperature in good to excellent yields. Copyright Taylor & Francis Group, LLC.