564-73-8

Basic information

• Product Name: Honokiol
• Synonyms: (2S)-1,2,3,4,4a,9,10,10aα-Octahydro-1,1,4aβ-trimethyl-7-isopropyl-2β,6-phenanthrenediol;Hinokiol;Hikiol
• CAS NO: 564-73-8
• Molecular Formula: C₂₀H₃₀O₂
• Molecular Weight: 302.45
• Mol File: 564-73-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 400.1°Cat760mmHg
• Flash Point: 184°C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 4.71E-08mmHg at 25°C
• Refractive Index: 1.548
• CAS DataBase Reference: Honokiol(CAS DataBase Reference)
• NIST Chemistry Reference: Honokiol(564-73-8)
• EPA Substance Registry System: Honokiol(564-73-8)

Safety Data

• Hazardous Substances Data: 564-73-8(Hazardous Substances Data)

Usage

General Description

Honokiol is a natural biphenolic compound found in the bark, seed cones, and leaves of the magnolia tree. It has been used in traditional Chinese and Japanese medicine for centuries due to its potential anti-inflammatory, anti-tumor, and neuroprotective properties. Honokiol has also been shown to have antioxidant and anti-anxiety effects, making it a promising candidate for the treatment of various medical conditions. Research has revealed that honokiol is able to modulate several signaling pathways in the body, making it a potential therapeutic agent for the treatment of cancer, cardiovascular diseases, and neurodegenerative disorders. Additionally, honokiol has been found to have sedative effects, which may be beneficial for the treatment of anxiety and insomnia. Overall, honokiol shows great potential for the development of novel medications for a wide range of health conditions.

InChI:InChI=1/C20H30O2/c1-12(2)14-10-13-6-7-17-19(3,4)18(22)8-9-20(17,5)15(13)11-16(14)21/h10-12,17-18,21-22H,6-9H2,1-5H3

Upstream product

• 18326-15-3 hinokiol diacetate 
• 145533-21-7 3-O-benzoylhinokiol 
• 472-37-7 hinokione 
• 64-17-5 ethanol 
• 64-19-7 acetic acid 
• 26804-77-3 abieta-5,6,11,13-tetraen-3-one 
• 78078-40-7 abieta-5,8,11,13-tetraten-3β-ol 
• 78078-43-0 3β-acetoxyabieta-8,11,13-triene 
• 78078-44-1 3β-acetoxy-12-acetylabieta-8,11,13-triene 
• 78078-41-8 abieta-8,11,13-trien-3β-ol 

Downstream Products

• 472-37-7 hinokione 
• 18326-15-3 hinokiol diacetate 
• 18326-13-1 12-methoxyabieta-8,11,13-trien-3β-ol 
• 483-65-8 Retene 
• 6314-07-4 2-Isopropyl-8-methyl-[3]phenanthrol 
• 33465-18-8 salviol 

Relevant articles and documents

Enantioselective, Lewis Base-Catalyzed Sulfenocyclization of Polyenes

A sulfenium-ion-initiated, catalytic, enantioselective polyene cyclization is described. Homogeranylarenes and ortho-geranylphenols undergo polycyclization in good yield, diastereoselectivity, and enantioselectivity. The stereodetermining step is the generation of an enantiomerically enriched thiiranium ion from a terminal alkene and a sulfenylating agent in the presence of a chiral Lewis basic catalyst. The use of hexafluoroisopropyl alcohol as the solvent is crucial to obtain good yields. The thioether moiety resulting from the reaction can be subsequently transformed into diverse oxygen and carbon functionality postcyclization. The utility of this method is demonstrated by the enantioselective syntheses of (+)-ferruginol and (+)-hinokiol.

ANTIMALARIAL COMPOUNDS FROM HOSLUNDIA OPPOSITA

Four new abietane-type esters, 3-O-benzoylhosloppone, 3-O-cinnamoylhosloppone, 3-O-benzoylhinokiol and 3-O-benzoylhosloquinone were isolated from the root bark of the antimalarial plant Hoslundia opposita Vahl. and their structures were determined by a combination of spectroscopic methods and chemical correlations. 3-O-Benzoylhosloppone inhibits the growth of the multidrug resistant strain K1 of Plasmodium falciparum in vitro with an IC50-value of 0.4 μg ml-1. Key Word Index: Hoslundia opposita Vahl.; Lamiaceae; 3-O-benzoylhosloppone; 3-O-cinnamoylhosloppone; 3-O-benzoylhinokiol; 3-O-benzoylhosloquinone; antimalarial activity.