56406-33-8

Basic information

• Product Name: 2-(4-Chloro-phenyl)-4-hydroxy-pyriMidine-5-carboxylic acid ethyl ester
• Synonyms: 2-(4-Chloro-phenyl)-4-hydroxy-pyriMidine-5-carboxylic acid ethyl ester;ethyl 2-(4-chlorophenyl)-6-oxo-1,6-dihydropyrimidine-5-carboxylate;ethyl 2-(4-chlorophenyl)-4-oxo-1,4-dihydropyrimidine-5-carboxylate
• CAS NO: 56406-33-8
• Molecular Formula: C₁₃H₁₁ClN₂O₃
• Molecular Weight: 278.69104
• Mol File: 56406-33-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-Chloro-phenyl)-4-hydroxy-pyriMidine-5-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Chloro-phenyl)-4-hydroxy-pyriMidine-5-carboxylic acid ethyl ester(56406-33-8)
• EPA Substance Registry System: 2-(4-Chloro-phenyl)-4-hydroxy-pyriMidine-5-carboxylic acid ethyl ester(56406-33-8)

Safety Data

• Hazardous Substances Data: 56406-33-8(Hazardous Substances Data)

Usage

Common uses

intermediate in the synthesis of pharmaceuticals and agrochemicals

Properties

antifungal, herbicidal, anti-inflammatory, and anti-tumor

Potential applications

development of new drugs and pesticides, treatment of various diseases

Usage

synthetic building block in the production of various organic compounds.

Upstream product

• 37555-99-0 diethyl ethoxymalonate 
• 14401-51-5 4-chlorobenzamidine hydrochloride 

Downstream Products

• 304693-56-9 ethyl 2-(4-chlorophenyl)-4-chloropyrimidine-5-carboxylate 
• 304693-58-1 ethyl 2-(4-chlorophenyl)pyrimidine-5-carboxylate 

Relevant articles and documents

Compounds

Pyrimidone compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in treating atherosclerosis.

Antiallergy agents. I. 1,6-dihydro-6-oxo-2-phenylpyrimidine-5-carboxylic acids and esters

The synthesis of some 1,6-dihydro-6-oxo-2-phenylpyrimidine-5-carboxylic acids and esters with potent oral and intravenous antiallergic activity against passive cutaneous anaphylaxis in the rat is described. Requirements for high activity include a free NH group in the pyrimidinone nucleus and a small to medium size ortho alkoxy or alkenyloxy group on the phenyl ring. It is suggested that in the case of the highly active compounds hydrogen bonding occurs between a nitrogen of the pyrimidine ring and the ethereal oxygen. The nature of this bonding and its possible contribution to an optimum configuration for the molecules is discussed.