56443-69-7

Basic information

• Product Name: Ethanone, 1-[3-methyl-4-(phenylmethoxy)phenyl]-
• CAS NO: 56443-69-7
• Molecular Formula: C16H16O2
• Molecular Weight: 240.302
• Mol File: 56443-69-7.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[3-methyl-4-(phenylmethoxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[3-methyl-4-(phenylmethoxy)phenyl]-(56443-69-7)
• EPA Substance Registry System: Ethanone, 1-[3-methyl-4-(phenylmethoxy)phenyl]-(56443-69-7)

Safety Data

• Hazardous Substances Data: 56443-69-7(Hazardous Substances Data)

Upstream product

• 876-02-8 4-hydroxy-3-methylphenyl methyl ketone 
• 100-39-0 benzyl bromide 
• 100-44-7 benzyl chloride 

Downstream Products

• 1313708-49-4 C₃₂H₃₈O₅ 
• 1313708-48-3 (R,E)-4-(4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenoxy)-4-methylpent-1-en-3-one 
• 1313708-50-7 (R,E)-2-(4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenoxy)-N-methoxy-N,2-dimethylpropanamide 
• 1313708-54-1 (R,E)-4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenol 
• 1313708-55-2 (S,Z)-4-(benzyloxy)-2-(5-(benzyloxy)pent-3-en-2-yl)-5-methylphenol 
• 1313708-52-9 (R,E)-1-(benzyloxy)-4-(1-(benzyloxy)pent-3-en-2-yloxy)-2-methylbenzene 
• 1292298-75-9 4-(2-(4-hydroxy-3,5-dimethylphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate 
• 1292299-05-8 2-(4-(hydroxy)-3,5-dimethylphenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate 
• 1292298-73-7 4-(2-(4-hydroxy-2-methylphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate 
• 1292299-03-6 2-(4-hydroxy-2-methylphenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate 
• 1292299-02-5 2-(4-(benzyloxy)-2-methylphenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate 
• 1292298-71-5 4-(2-(4-hydroxy-3-methylphenyl)-2-oxoethoxy)-4-oxobutan-1-aminium-2,2,2-trifluoroacetate 
• 1292299-01-4 2-(4-hydroxy-3-methylphenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate 
• 1292299-00-3 2-(4-(benzyloxy)-3-methylphenyl)-2-oxoethyl-4-(tert-butoxycarbonylamino)butanoate 

Relevant articles and documents

Total synthesis of heliannuol B, an allelochemical from Helianthus annuus

A total synthesis of the allelochemical heliannuol B 1 is described employing ring closing metathesis to generate the central benzoxepane ring system.

(THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS

The present invention relates to (thio)morpholine derivatives of the formula (I), wherein R1 is selected from cyano, (2-4C)alkynyl, (1-4C)alkyl, (3-6C)cycloalkyl, (4-6C)cycloalkenyl, (6-8C)bicycloalkyl, (8-10C)bicyclic group, each optionally substituted with (1-4C)alkyl, phenyl, biphenyl, naphthyl, each optionally substituted with one or more substituents independently selected from halogen, (1-4C)alkyloptionally substituted with one or more fluoro atoms, (2-4C)alkynyl, (1-4C)alkoxy optionally substituted with one or more fluoro atoms,amino, di(1-4C)alkylamino, -SO2-(1-4C)alkyl, -CO-(1-4C)alkyl, -CO-O-(1-4C)alkyl, -NH-CO-(1-4C)alkyl and (3-6C)cycloalkyl, phenyl substituted with phenoxy, benzyl, benzyloxy, phenylethyl or monocyclic heterocycle, each optionally substituted with (1-4C)alkyl, monocyclic heterocycle optionally substituted with halogen, (1-4C)alkyl or with phenyl optionally substituted with (1-4C)alkyl, and bicyclic heterocycle optionally substituted with (1-4C)alkyl; A is selected from -CO-O-, -O-CO-, -NH-CO-, -CO-NH, -C=C-, -CCH3-O- and the linking group –Y-(CH2)n-X- wherein Y is attached to R1 and selected from a bond, -O-, -S-, -SO-, -SO2-, -CH2-O-, -CO-, -O-CO-, -CO-O-, -CO-NH-, -NH-CO-, -C=C-and -C≡C-; n is an integer from 1 to 10; and X is attached to the phenylene / pyridyl group and selected from a bond, -O-, -S-, -SO-, -SO2 -, -NH, -CO-, -C=C-and -C≡C-; ring structure B optionally contains one nitrogen atom; R2 is H, (1-4C)alkyl optionally substituted with one or more fluoro atoms, (1-4C)alkoxy optionally substituted with one or more fluoro atoms, or halogen; and R3 is (1-4C)alkylene-R5 wherein the alkylene group may be substituted with (CH2)2 to form a cyclopropyl moiety or one or two halogen atoms, or R3 is is (3-6C)cycloalkylene-R5 or -CO-CH2-R5, wherein R5 is -OH, -PO3H2, -OPO3H2, -COOH, -COO(1-4C)alkyl or tetrazol-5-yl; R4 is H or (1-4C)alkyl; R6 is one or more substituents independently selected from H, (1-4C)alkyl or oxo; W is -O-, -S-, -SO- or -SO2-; or a pharmaceutically acceptable salt, a solvate or hydrate thereof; with the proviso that the derivative of formula (I) is not 2-(4-ethylphenyl)-4-morpholinoethanol or 4-[4-(2-hydroxyethyl)-2-morpholinyl]benzeneacetonitrile or a pharmaceutically acceptable salt, a solvate or hydrate thereof. The compounds of the invention have affinity to S1P receptors and may be used in the treatment, alleviation or prevention of S1P receptor mediated diseases and conditions.

DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE β2 ADRENERGIC RECEPTOR

The present invention provides a Compound of formula (I), wherein: R1 is a group selected from -CH2OH,-NH(CO)H; and R2 is a hydrogen atom; or R1 together with R2 form the group -NH-C(O)-CH=CH-, wherei