56452-54-1

Basic information

• Product Name: 1-Cyclohexene-1-methanol, 4-(1-methylethenyl)-, acetate, (4R)-
• CAS NO: 56452-54-1
• Molecular Formula: C12H18O2
• Molecular Weight: 194.274
• Mol File: 56452-54-1.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1-Cyclohexene-1-methanol, 4-(1-methylethenyl)-, acetate, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclohexene-1-methanol, 4-(1-methylethenyl)-, acetate, (4R)-(56452-54-1)
• EPA Substance Registry System: 1-Cyclohexene-1-methanol, 4-(1-methylethenyl)-, acetate, (4R)-(56452-54-1)

Safety Data

• Hazardous Substances Data: 56452-54-1(Hazardous Substances Data)

Upstream product

• 5503-12-8 L-perillaldehyde 
• 56246-58-3 β-pinene oxide 
• 108-24-7 acetic anhydride 
• 875-08-1 (-)-β-Pinenoxid 
• 581-55-5 benzylidene 1,1-diacetate 
• 536-59-4 (-)-perillyl alcohol 
• 18031-40-8 (S)-(-)-perillaldehyde 
• 5989-54-8 (-)-(S)-limonene 
• 64-18-6 formic acid 
• 5989-27-5 D-limonene 
• 64-19-7 acetic acid 
• 216655-61-7 (5R)-2-methylene-5-(1-methylethenyl)-1-cyclohexanol 
• 1195-92-2 (4R)-limonene 1,2-epoxide 
• 57717-97-2 (R)-Perillyl alcohol 

Downstream Products

• 1637633-33-0 C₂₁H₃₀N₂O₂ 
• 1637633-32-9 C₂₁H₃₀N₂O₂ 
• 1637633-31-8 C₁₇H₃₀N₂O 
• 1637633-30-7 C₁₆H₂₈N₂O 
• 1637633-36-3 C₁₅H₂₀N₂O 
• 1637633-35-2 C₁₅H₂₅NO 
• 1637633-34-1 C₂₁H₃₀N₂O 

Relevant articles and documents

A further step to sustainable palladium catalyzed oxidation: Allylic oxidation of alkenes in green solvents

The palladium catalyzed oxidation of alkenes with molecular oxygen is a synthetically important reaction which employs palladium catalysts in solution; therefore, a solvent plays a critical role for the process. In this study, we have tested several green solvents as a reaction medium for the allylic oxidation of a series of alkenes. Dimethylcarbonate, methyl isobutyl ketone, and propylene carbonate, solvents with impressive sustainability ranks and very scarcely exploited in palladium catalyzed oxidations, were proved to be excellent alternatives for the solvents conventionally employed in these processes, such as acetic acid. Palladium acetate alone or in the combination with p-benzoquinone efficiently operates as the catalyst for the oxidation of alkenes by dioxygen under 5–10 atm. For most substrates, the systems in green solvents showed better selectivity for allylic oxidation products as compared to pure acetic acid; moreover, the reactions in propylene carbonate solutions occurred even faster than in acetic acid.

Perilla alcohol derivative and its preparation and use

The invention belongs to the technical field of medicine, and relates to a series of perilla alcohol derivatives disclosed as Formula I, and preparation and application thereof. The invention also relates to pharmaceutically acceptable salts and solvates of the perilla alcohol derivatives, and a pharmaceutical composition containing the perilla alcohol derivatives or pharmaceutically acceptable salts thereof as active components, which can be used for treating cancers. The perilla alcohol derivatives and pharmaceutical salts thereof have favorable anticancer activity. The preparation method is simple and feasible, and is easy to operate.

Synthesis and antiproliferative effects of amino-modified perillyl alcohol derivatives

Two series of amino-modified derivatives of (S)-perillyl alcohol were designed and synthesized using (S)-perillaldehyde as the starting material. These derivatives showed increased antiproliferative activity in human lung cancer A549 cells, human melanoma A375-S2 cells and human fibrosarcoma HT-1080 cells comparing with that of (S)-perillyl alcohol. Among these derivatives, compounds VI5 and VI7 were the most potent agents, with the IC50s below 100 μM. It was demonstrated that the antiproliferative effect of VI5 was mediated through the induction of apoptosis in A549 cells.