565-33-3 Usage
Description
Metahexamide is a compound utilized in various applications, particularly in the field of biological studies and pharmaceutical research. It is known for its ability to assess the impact of certain substances on blood urea nitrogen levels in both dogs and human subjects.
Uses
Used in Pharmaceutical Research:
Metahexamide is used as a research tool for evaluating the effects of chloral hypnotics on the elevation of blood urea nitrogen levels in dogs and human subjects. This application aids in understanding the potential side effects and safety profiles of these hypnotics, contributing to the development of safer and more effective medications.
Used in Biological Studies:
In the context of biological studies, metahexamide serves as an important compound for investigating the physiological responses to specific substances. By examining the changes in blood urea nitrogen levels, researchers can gain insights into the metabolic processes and potential health implications associated with the use of certain drugs or treatments.
Originator
Metahexamide ,Shanghai Lansheng
Manufacturing Process
39 g ethyl chloroformate are added dropwise to a mixture of 68.4 g 3- acetylamino-p-toluene sulphonic acid amide, 123 g potassium carbonate and 450 ml acetone for one hour while boiling under reflux. Refluxing is then continued for a further nine hours. The reaction mixture is cooled and mixed, while stirring, with a mixture of 450 ml water and 50 ml 2 N potassium hydroxide solution. Thereby two layers are formed. The upper layer, which consists of aqueous acetone, is separated. Acetone is distilled off in a vacuum. The pH-value of the resulting aqueous solution is adjusted to a pH of 8.8 by passing in gaseous carbon dioxide. Precipitated unchanged starting material is filtered off. The filtrate is rendered congo acid by the addition of dilute hydrochloric acid. The precipitated 3-acetylamino-p-toluene sulfnyl ethyl urethane is filtered off by suction, washed with water, and dried in a vacuum. The yield is 77%. The resulting compound melts at 183°-194°C. 54.3 g above prepared 3-acetylamino-p-toluene sulphonyl ethyl urethane are mixed with 37 ml dimethylformamide and 18 g cyclohexylamine. The resulting clear solution is heated at 70°C for 1.5 hours and at 110°C for 1.5 more
hours. After cooling, the reaction mixture is poured into 500 ml water while
stirring. The precipitated oily product crystallizes shortly. The crystals are
filtered off by suction, washed with water and dried in a vacuum. Yield of 3-
acetylamino-p-toluene sulphonyl cyclohexyl urea is 84%. MP: 174°C. The urea
is saponified without further purification by heating it in 90 ml 5 N potassium
hydroxide solution at 90°C for one hour. After dilution with 500 ml water the
resulting reaction mixture is rendered acid (pH 6.5) by the addition of dilute
hydrochloric acid. Thereby, 1-(3-amino-p-tolylsulfonyl)-3-cyclohexylurea
separates in crystals, which are collected, washed with water, and dried. The
yield is 86%. After recrystallization from ethanol the compound has MP: 151°-
152°C.
Therapeutic Function
Oral hypoglycemic
Check Digit Verification of cas no
The CAS Registry Mumber 565-33-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,6 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 565-33:
(5*5)+(4*6)+(3*5)+(2*3)+(1*3)=73
73 % 10 = 3
So 565-33-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H21N3O3S/c1-10-7-8-12(9-13(10)15)21(19,20)17-14(18)16-11-5-3-2-4-6-11/h7-9,11H,2-6,15H2,1H3,(H2,16,17,18)
