565-92-4

Basic information

• Product Name: 3ALPHA,11B-Dihydroxy-5B-pregnan-20-one
• Synonyms: 3ALPHA,11B-Dihydroxy-5B-pregnan-20-one
• CAS NO: 565-92-4
• Molecular Formula: C₂₁H₃₄O₃
• Molecular Weight: 334.49
• Mol File: 565-92-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 469.7±40.0 °C(Predicted)
• Appearance: /
• Density: 1.117±0.06 g/cm3(Predicted)
• PKA: 14.65±0.70(Predicted)
• CAS DataBase Reference: 3ALPHA,11B-Dihydroxy-5B-pregnan-20-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3ALPHA,11B-Dihydroxy-5B-pregnan-20-one(565-92-4)
• EPA Substance Registry System: 3ALPHA,11B-Dihydroxy-5B-pregnan-20-one(565-92-4)

Safety Data

• Hazardous Substances Data: 565-92-4(Hazardous Substances Data)

Upstream product

• 565-99-1 3α-hydroxy-5β-pregnane-11,20-dione 
• 96464-92-5 3α-acetoxy-11β-hydroxy-5β-pregnan-20-one 
• 15807-40-6 20,20-ethanediyldioxy-5β-pregnane-3α,11β-diol 
• 1610-52-2 3α-acetoxy-5β-pregnane-11,20-dione 
• 15807-38-2 20,20-ethanediyldioxy-3α-hydroxy-5β-pregnan-11-one 
• 80-75-1 11-alpha-hydroxyprogesterone 
• 565-94-6 11α-hydroxy-5β-pregnane-3,20-dione 
• 600-52-2 3α,11α-dihydroxy-5β-pregnan-20-one 
• 115267-39-5 20,20-ethanediyldioxy-5β-pregnane-3α,11α-diol 

Downstream Products

• 55176-88-0 11β-hydroxy-5β-pregnane-3,20-dione 
• 600-57-7 (8S,9S,10R,11S,13S,14S,17S)-17-Acetyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 50-22-6 Corticosterone 
• 1173-26-8 corticosterone-21-acetate 

Relevant articles and documents

Allopregnanolone and pregnanolone analogues modified in the C ring: Synthesis and activity

(25R)-3β-Hydroxy-5α-spirostan-12-one (hecogenin) and 11α-hydroxypregn-4-ene-3,20-dione (11α-hydroxyprogesterone) were used as starting materials for the synthesis of a series of 11- and 12-substituted derivatives of 5ξ-pregnanolone (3α-hydroxy-5α- pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one), the principal neurosteroid acting via γ-aminobutyric acid (GABA). These analogues were designed to study the structural requirements of the corresponding GABA A receptor. Their biological activity was measured by in vitro test with [3H]flunitrazepam as radioligand in which allopregnanolone and its active analogues stimulated the binding to the GABAA receptor. Analysis of the SAR data suggests dependence of the flunitrazepam binding activity on the hydrophobic-hydrophilic balance of the groups at the C-ring edge rather than on specific interactions between them and the receptor.