56506-61-7

Basic information

• Product Name: N-CYCLOHEXYL-4-CHLOROANILINE
• Synonyms: N-Cyclohexyl-4-Chloroaniline(WXC04198)
• CAS NO: 56506-61-7
• Molecular Formula: C₁₂H₁₆ClN
• Molecular Weight: 209.72
• Mol File: 56506-61-7.mol
• Article Data: 35

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-CYCLOHEXYL-4-CHLOROANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CYCLOHEXYL-4-CHLOROANILINE(56506-61-7)
• EPA Substance Registry System: N-CYCLOHEXYL-4-CHLOROANILINE(56506-61-7)

Safety Data

• Hazardous Substances Data: 56506-61-7(Hazardous Substances Data)

Usage

Description

N-Cyclohexyl-4-chloroaniline is a chemical compound that features a cyclohexyl group connected to a 4-chloroaniline molecule. It is recognized for its role as an intermediate in the synthesis of dyes and pharmaceuticals, and it is also known for its toxic properties, which necessitate careful handling and disposal to prevent harm to human health and the environment.

Uses

Used in Pharmaceutical Industry:
N-Cyclohexyl-4-chloroaniline is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Dye Industry:
In the dye industry, N-Cyclohexyl-4-chloroaniline serves as an essential intermediate in the production of a range of dyes. Its chemical properties make it suitable for creating dyes with specific characteristics, such as color intensity and stability.

Upstream product

• 108-94-1 cyclohexanone 
• 106-47-8 4-chloro-aniline 
• 108-85-0 1-bromocyclohexane 
• 68230-00-2 1-Cyclopentoxy-5-chloro-1,2,3-benzotriazole 
• 68230-01-3 1-Cyclohexoxy-5-chloro-1,2,3-benzotriazole 
• 68230-02-4 1-Cycloheptoxy-5-chloro-1,2,3-benzotriazole 
• 788-92-1 cyclohexyl p-nitrobenzenesulfonate 
• 953-91-3 cyclohexyl tosylate 
• 782-84-3 Cyclohexyl benzenesulphonate 
• 69564-61-0 cyclohexyl p-chlorobenzenesulfonate 
• 106-39-8 bromochlorobenzene 
• 108-91-8 cyclohexylamine 
• 637-87-6 1-Chloro-4-iodobenzene 
• 4441-56-9 cyclohexylboronic acid 

Downstream Products

• 1451061-09-8 5-chloro-1-cyclohexylindoline-2,3-dione 

Relevant articles and documents

Halogenated method of aromatic compound

The invention belongs to the field of organic synthesis, and particularly relates to synthesis of aromatic halogens, in particular to arylamine. The invention discloses a synthesis method of a corresponding ortho-halogenated product from aromatic compounds such as carbazole and phenol. The method comprises the following steps: adding a metal sulfonate salt catalyst, aromatic amine, carbazole, phenol and other hydrogen - heteroatom-containing aromatic compound reaction substrates, a halogenation reagent and a reaction solvent at a specific reaction temperature. After the drying agent is dried, the yield of the reaction product and the nuclear magnetic characterization determining structure are determined by column chromatography. The reaction product yield is determined by gas chromatography. By adopting the method, under the cheap metal salt catalyst, a plurality of ortho-substituted brominated and chloro products can be obtained with moderate to excellent yield.

Visible-Light-Enabled Direct Decarboxylative N-Alkylation

The development of efficient and selective C?N bond-forming reactions from abundant feedstock chemicals remains a central theme in organic chemistry owing to the key roles of amines in synthesis, drug discovery, and materials science. Herein, we present a dual catalytic system for the N-alkylation of diverse aromatic carbocyclic and heterocyclic amines directly with carboxylic acids, by-passing their preactivation as redox-active esters. The reaction, which is enabled by visible-light-driven, acridine-catalyzed decarboxylation, provides access to N-alkylated secondary and tertiary anilines and N-heterocycles. Additional examples, including double alkylation, the installation of metabolically robust deuterated methyl groups, and tandem ring formation, further demonstrate the potential of the direct decarboxylative alkylation (DDA) reaction.

Oxidative Rearrangement of Primary Amines Using PhI(OAc)2 and Cs2CO3

An oxidative rearrangement of primary amines mediated by a hypervalent iodine(III) reagent is herein reported. The combination of PhI(OAc)2 and Cs2CO3 proves highly efficient at inducing the direct 1,2-C to N migration of primary amines, which can be applied to the preparation of both acyclic and cyclic amines. A mechanistic study shows that the rearrangement proceeds via a concerted mechanism.