5651-55-8

Basic information

• Product Name: AKOS 227-02
• Synonyms: AKOS 227-02;RARECHEM AL BE 1076;3-(benzyloxy)-4,5-dimethoxybenzoic acid
• CAS NO: 5651-55-8
• Molecular Formula: C₁₆H₁₆O₅
• Molecular Weight: 288.3
• Mol File: 5651-55-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 440.8°Cat760mmHg
• Flash Point: 161.5°C
• Appearance: /
• Density: 1.228g/cm³
• Vapor Pressure: 1.51E-08mmHg at 25°C
• Refractive Index: 1.576
• CAS DataBase Reference: AKOS 227-02(CAS DataBase Reference)
• NIST Chemistry Reference: AKOS 227-02(5651-55-8)
• EPA Substance Registry System: AKOS 227-02(5651-55-8)

Safety Data

• Hazardous Substances Data: 5651-55-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H16O5/c1-19-13-8-12(16(17)18)9-14(15(13)20-2)21-10-11-6-4-3-5-7-11/h3-9H,10H2,1-2H3,(H,17,18)

Upstream product

• 180900-29-2 2-(3-Benzyloxy-4,5-dimethoxy-benzoyl)-4-oxo-4-(3,4,5-trimethoxy-phenyl)-butyric acid ethyl ester 
• 26409-24-5 methyl 3-benzyloxy-4,5-dimethoxybenzoate 

Downstream Products

• 5320-34-3 3,4-Dimethoxy-5-benzyloxyphenylaceticacid 
• 5065-11-2 3-benzyloxy-4,5-dimethoxybenzoyl chloride 
• 901125-30-2 (-)-(2R,3R)-cis-5,7-bis(benzyloxy)-2-[3',4'-bis(benzyloxy)-phenyl]chroman-3-yl 3''-benzyloxy-4'',5''-dimethoxybenzoate 
• 901125-43-7 (-)-(2R,3R)-cis-5,7-bis(benzyloxy)-2-[3',5'-bis(benzyloxy)-4'-methoxyphenyl]chroman-3-yl 3''-benzyloxy-4'',5''-dimethoxybenzoate 
• 1027080-33-6 [1-(3-Benzyloxy-4,5-dimethoxy-phenyl)-vinyloxy]-trimethyl-silane 
• 143418-80-8 3-Benzyloxy-4,5-dimethoxyacetophenone 
• 180900-27-0 ethyl-(3-benzyloxy-4,5-dimethoxy)benzoylacetate 
• 180900-57-6 1,4-Bis-(3-benzyloxy-4,5-dimethoxy-phenyl)-butane-1,4-dione 
• 180900-29-2 2-(3-Benzyloxy-4,5-dimethoxy-benzoyl)-4-oxo-4-(3,4,5-trimethoxy-phenyl)-butyric acid ethyl ester 

Relevant articles and documents

Synthesis and evaluation of 3-aroylindoles as anticancer agents: Metabolite approach

BPR0L075 (2) is a potential anticancer drug candidate designed from Combretastatin A-4 (1) based on the bioisosterismprinciple.Metabolites of 2, proposed from in vitrohumanmicrosome studies,were synthesized, leading to the identification of metabolite-der

Synthesis and PAF antagonist activity of some 2,5-diaryltetrahydrofurans incorporating PAF-like functional groups

This paper describes the synthesis and structure-activity relationships of a series of 2,5-diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the known PAF antagonist L-652,731 were replaced with functional groups present in PAF and in the 'PAF-like' antagonists. Activity was generally retained or enhanced when one aryl ring in L-652,731 was elaborated; however incorporation of these functional groups into both of the aryl rings greatly reduced or abolished activity. These results are discussed in relation to a putative model for the PAF receptor.