56517-32-9Relevant articles and documents
Lamellarin-inspired potent topoisomerase I inhibitors with the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one scaffold
Fukuda, Tsutomu,Nanjo, Yusuke,Fujimoto, Masahiro,Yoshida, Kenyu,Natsui, Yuko,Ishibashi, Fumito,Okazaki, Fumiyasu,To, Hideto,Iwao, Masatomo
, p. 265 - 277 (2019)
A new class of topoisomerase I inhibitors containing the unprecedented benzo[g][1]benzopyrano[4,3-b]indol-6(13H)-one (abbreviated as BBPI) ring system have been developed based on structure-activity relationship studies of the cytotoxic marine alkaloid la
Synthesis and evaluation of topoisomerase I inhibitors possessing the 5,13-dihydro-6H-benzo[6,7]indolo[3,2-c]-quinolin-6-one scaffold
Fukuda, Tsutomu,Matsuo, Yuri,Matsuoka, Fuyuki,Yoshioka, Naoki,Onodera, Gen,Kimura, Masanari,Ishibashi, Fumito,Iwao, Masatomo
, p. 1032 - 1052 (2019/07/31)
Novel topoisomerase I inhibitors possessing the 5,13-dihydro-6H-benzo[6,7]indolo[3,2-c]quinolin-6-one (BIQ) scaffold were designed and synthesized. This scaffold was constructed using sequential and regioselective functionalization of the pyrrole core thr
Efficient One-Pot Synthesis of Tetrahydronaphtho[2,1-f]isoquinolines by Using Domino Pictet–Spengler/Friedel–Crafts-Type Reactions
Khunnawutmanotham, Nisachon,Sahakitpichan, Poolsak,Chimnoi, Nitirat,Techasakul, Supanna
, p. 6434 - 6440 (2017/12/01)
This study describes a facile and efficient one-pot method for the synthesis of a tetrahydronaphtho[2,1-f]isoquinoline alkaloid. An N-protected amino aldehyde biaryl substrate underwent domino Pictet–Spengler/Friedel–Crafts-type cyclization reactions to p