565470-52-2Relevant articles and documents
Synthesis of 5-carbonyl-1,3-dihydro-1,3-dioxo-2H-isoindole-2-propanoic acid integrin antagonists
Deng, Yong,Shen, Yi,Zhong, Yu-Guo
, p. 2109 - 2117 (2007/10/03)
The 5-carboxy-1,3-dihydro-1,3-dioxo-2H-isoindole-2-propanoic acid benzyl ester (I), obtained from condensation of 1,3-dihydro-1,3-dioxo-5-isobenzofurancarboxylic acid with β-alanine benzyl ester p-toluenesulfonate, reacted with an appropriate amine (II) to afford the corresponding amide (IIIa-e), which then hydrogenolyzed by 5% palladium-on-carbon to give target compounds (IVa-e).