5657-61-4Relevant articles and documents
Biotransformation of nicotinamide to nicotinyl hydroxamic acid at bench scale by amidase acyl transfer activity of Pseudomonas putida BR-1
Bhatia, Ravi Kant,Bhatia, Shashi Kant,Mehta, Praveen Kumar,Bhalla, Tek Chand
, p. 89 - 95 (2014)
Acyl transfer activity of amidase of Pseudomonas putida BR-1 has been explored for the conversion of N-substituted aromatic amide (nicotinamide) and hydroxylamine to nicotinyl hydroxamic acid. Nicotinyl hydroxamic acid is an important pharmaceutical compound with enormous biomedical applications. P. putida BR-1 produces maximum amidase acyl transfer activity 138 U/mg dcm at 50 °C, with highest conversion (95%) of nicotinamide to nicotinyl hydroxamic acid. A bioprocess was developed for production of nicotinyl hydroxamic acid in batch reaction (final volume 1 L) by adding 200 mM nicotinamide and 1000 mM of hydroxylamine in 100 mM sodium phosphate buffer (pH 7.5) at 50 °C, using 20 U/ml acyl transfer activity resting cells of P. putida BR-1 in reaction mixture. From 1 L reaction mixture 16 g of nicotinyl hydroxamic acid was recovered with 32 g/L/h volumetric productivity. The amidase acyl transfer activity of P. putida BR-1 and the process developed in the present study are of industrial significance for the enzyme mediated production of nicotinyl hydroxamic acid.
Photoinduced one-pot synthesis of hydroxamic acids from aldehydes through in-situ generated silver nanoclusters
Mohamed, Yasser M. A.,Attia, Yasser A.,Solum, Eirik Johansson
, p. 7173 - 7186 (2018/08/17)
Hydroxamic acids have attracted significant attention due to their widespread use in applied chemistry. In this report, a modified Angeli–Rimini method has been achieved via the visible light-mediated catalytic transformation of a variety of heterocyclic, aromatic and aliphatic aldehydes 1a–j to their corresponding hydroxamic acids 2a–j in 81–93% yield. The unique ability of vitamin K3 as a photoredox catalyst to expedite the development of completely new reaction mechanisms and to enable the construction of challenging carbon–nitrogen bonds has been investigated. It is shown for the first time that the vitamin K3 and aldehyde are largely responsible for rapid in situ reduction of Ag+ ions to catalytic photoluminescent Ag nanoclusters that possess a bandgap energy of 2.87?eV and are less than 2 nm in size. A mechanism for this reaction has been proposed and is supported by UV–Vis, TEM, ESI/MS, FT-IR, 1H NMR and 13C NMR analyses. The investigated method utilizes readily available reagents and produces the hydroxamic acids in high yields without the formation of side products, making it simple, practical and cost-effective.
HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF
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Page/Page column 46, (2012/09/10)
The present invention provides novel compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of a compound of the invention to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
