56577-02-7 Usage
Pharmacological Effects
S-nitroso-N-acetylcysteine (SNAC) is an S-nitrosothiol that can act as an Nitric oxide (NO) carrier and donor. NO has a systemic and tissue vasodilatation effect and also acts in hepatic microcirculation.S-nitroso-N-acetylcysteine (SNAC) acts an NO donor in the prevention of liver I/R injury in an animal mode. Experimental results demonstrated that SNAC solution showed a greater protective effect to preserve rat livers during cold storage.
Wellington Andraus and team hypothesized that S-nitroso-N-acetylcysteine (SNAC), an NO donor component, can ameliorate cell damage from IR injury. They studied the effect of SNAC on liver IR in rats with normal livers compared to those with steatotic livers, and the research results show that SNAC effectively protects against IR injury in steatotic livers but not in normal livers.
Previous studies have shown that SNAC prevents nonalcoholic fatty liver disease in rats?and promotes down-regulation of several genes linked to glutathione synthesis and fatty acid metabolism. Thus, SNAC may be an interesting candidate for the treatment of human fibrosis and cirrhosis.
Antioxidant in Cured mMat
S-nitroso-N-acetylcysteine(SNAC) also acts as an antioxidant in cured meat.SNAC seems to be a good candidate molecule for the replacement of nitrite in meat products. S-nitroso-N-acetylcysteine(SNAC) at concentration like nitrite used by the industry prevents lipid peroxidation in the product, even after storage for 1 month at 4 °C. In condition like those used by the industry for meat products processing, SNAC acts better than nitrite to provide antioxidant protection without the side effect of N-nitrosation, oxidation, and the loss of nutrient generated by nitrite.
Check Digit Verification of cas no
The CAS Registry Mumber 56577-02-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,6,5,7 and 7 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 56577-02:
(7*5)+(6*6)+(5*5)+(4*7)+(3*7)+(2*0)+(1*2)=147
147 % 10 = 7
So 56577-02-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H8N2O4S/c1-3(8)6-4(5(9)10)2-12-7-11/h4H,2H2,1H3,(H,6,8)(H,9,10)/t4-/m0/s1
56577-02-7Relevant articles and documents
Capillary zone electrophoretic detection of biological thiols and their S-nitrosated derivatives
Stamler, Jonathan S.,Loscalzo, Joseph
, p. 779 - 785 (2007/10/02)
Reduced thiols (RSH) react with certain oxides of nitrogen to yield S-nitroso thiols (RSNO) possessing smooth muscle relaxant and platelet inhibitory properties. Nitrosated derivatives of the biological thiols - glutathione, cysteine, and homocysteine - have therefore been considered as bioactive intermediates in the metabolism of organic nitrates and the endothelium-derived relaxing factor with properties of nitric oxide. As yet, however, there is no established chemical method for identifying the biological S-nitroso thiols and, consequently, litttle is known of their distinguishing chemical characteristics or biochemistry. In this study, we demonstrate for the first time a simple, rapid, and reproducible method for separating these thiols from their S-nitrosated derivatives using capillary zone electrophoresis. Cysteine, homocysteine, and glutathione were separated from one another and from their corresponding disulfides in 0.01 M phosphate buffer, pH 2.5, by capillary zone electrophoresis and absorbance detection at 200 nm with measured elution times of 5.92-16.15 min; corresponding S-nitroso thiols were selectively detected at 320 nm and eluted at 2.50-18.20 min. These data support the specificity and reproducibility of this technique for separation and identification of thiols, disulfides, and S-nitroso thiol derivatives.
