5659-34-7

Basic information

• Product Name: 4-phenylquinoline 1-oxide
• Synonyms: 4-phenylquinoline 1-oxide
• CAS NO: 5659-34-7
• Molecular Weight: 221.258
• Mol File: 5659-34-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-phenylquinoline 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenylquinoline 1-oxide(5659-34-7)
• EPA Substance Registry System: 4-phenylquinoline 1-oxide(5659-34-7)

Safety Data

• Hazardous Substances Data: 5659-34-7(Hazardous Substances Data)

Upstream product

• 64097-92-3 2-(1-phenylvinyl)aniline 
• 536-74-3 phenylacetylene 
• 62-53-3 aniline 
• 605-03-8 4-phenylquinoline 
• 2311-91-3 monoperoxyphthalic acid 

Downstream Products

• 5855-58-3 4-phenylquinoline-2-carbonitrile 
• 5855-56-1 2-chloro-4-phenylquinoline 
• 1039-51-6 2,4-diphenylquinoline 

Relevant articles and documents

PEG-400 as a carbon synthon: Highly selective synthesis of quinolines and methylquinolines under metal-free conditions

A metal-free, peroxide-free, and efficient procedure for the highly selective synthesis of quinolines and methylquinolines was reported. The main feature of this method was that the same substrate can produce quinolines and methylquinolines, respectively, under different reaction conditions. PEG-400 was used as both a reactant and solvent in this reaction. The utility of the designed procedure was also demonstrated by the derivatization of the products to bioactive compounds. This journal is

Hypervalent Iodine(III)-Mediated Regioselective Cyanation of Quinoline N-Oxides with Trimethylsilyl Cyanide

A regioselective cyanation of quinoline N-oxides with trimethylsilyl cyanide was developed by using (Diacetoxyiodo) benzene (PIDA) as mediated hypervalent iodine(III) reagent under metal-free and base-free reaction conditions to obtain 2-cyanoquinolines. The efficient PIDA reagent could play the role of an activator of the substrates and an accelerator of N?O bond cleavage. The reaction system featured a wide range of substrate suitability and high yields. The procedure was enlarged gram-scale to synthesize the tuberculosis (TB) inhibitor. Finally, according to some experimental results, a plausible mechanism for the cyanation reaction is proposed. (Figure presented.).

Copper-catalyzed intermolecular dehydrogenative amidation/amination of quinoline N-oxides with lactams/cyclamines

C-H, N-H dehydrogenative coupling of quinoline N-oxides with lactams/cyclamines has been achieved in the presence of the Cu(OAc)2 catalyst to give good to excellent yields. This study provides a new strategy for the construction of a 2-aminoqui