5661-46-1

Basic information

• Product Name: N-(3-aMinophenylsulfonyl)acetaMide
• Synonyms: N-(3-aMinophenylsulfonyl)acetaMide
• CAS NO: 5661-46-1
• Molecular Formula: C₈H₁₀N₂O₃S
• Molecular Weight: 214.2416
• Mol File: 5661-46-1.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(3-aMinophenylsulfonyl)acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-aMinophenylsulfonyl)acetaMide(5661-46-1)
• EPA Substance Registry System: N-(3-aMinophenylsulfonyl)acetaMide(5661-46-1)

Safety Data

• Hazardous Substances Data: 5661-46-1(Hazardous Substances Data)

Upstream product

• 64-19-7 acetic acid 
• 98-18-0 m-aminobenzenesulfonamide 
• 23530-45-2 1-(methylcarbonylaminosulphonyl)-3-nitrobenzene 
• 121-52-8 3-nitrophenylsulfonamide 

Downstream Products

• 1445879-62-8 N-((3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)phenyl)sulfonyl)acetamide 

Relevant articles and documents

CHEMICAL COMPOUNDS

The invention is directed to substituted quinoline derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R, R1, R2, R3 and R4 are defined herein. The compounds of the invention are inhibitors of lactate dehydrogenase A and can be useful in the treatment of cancer and diseases associated with tumor cell metabolism, such as cancer, and more specifically cancers of the breast, colon, prostate and lung. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting lactate dehydrogenase A activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Benzodiazepine derivatives, compositions containing them and their use in therapy

Compounds of formula (I), and salts and prodrugs thereof wherein: R1 represents optionally substituted C? ??alkyl or C???cycloalkyl; R2 represents an optionally substituted phenyl or pyridyl group; R3 represents C??? alkyl or halo; R? represents C??? cycloalkyl; X is 0, 1, 2 or 3; are CCK and/or gastrin antagonists. They and compositions thereof are therefore useful in therapy.