566155-74-6Relevant articles and documents
Compound a preparation UNC1215 method
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, (2017/03/14)
The invention discloses a method for preparing a compound UNC1215, belonging to the technical field of pharmaceutical chemistry synthesis. The method sequentially comprises the following steps: nitration, nitro reduction reaction, Buchwald reaction, esterolysis reaction, condensation reaction and the like. The overall reaction yield can reach 67%, which is higher than the yield (60%) in the document. The method changes the synthesis route, avoids the pipe sealing reaction, sequentially performs the nitration, reduction reaction, Buchwald reaction, hydrolysis reaction and condensation reaction, and is simple to operate.
Metal-free synthesis of secondary arylamines: An aliphatic-to-aromatic transformation
Barros, M. Teresa,Dey, Suvendu S.,Maycock, Christopher D.
supporting information, p. 742 - 747 (2013/03/13)
An efficient method for the N-arylation of primary and some secondary amines using 2-halocyclohex-2-enones in an aliphatic-to-aromatic transformation in the presence of a substoichiometric amount of pTsOH has been developed. A series of arylamines have been synthesized from 2-halocyclohex-2-enones by in situ enamine formation followed by aromatization under environmentally friendly conditions using pTsOH. This metal-free, practical, relatively inexpensive protocol is of value in organic synthesis for industrial and academic applications. Copyright
