566155-76-8

Basic information

• Product Name: 4-PYRIDINEMETHANAMINE, ALPHA,ALPHA-DIMETHYL-
• Synonyms: 4-PYRIDINEMETHANAMINE, ALPHA,ALPHA-DIMETHYL-;4-Pyridinemethanamine,alpha,alpha-dimethyl-(9CI);2-(pyridin-4-yl)propan-2-amine;2-(4-Pyridyl)-2-propylaMine;a,a-diMethyl-4-PyridineMethanaMine
• CAS NO: 566155-76-8
• Molecular Formula: C8H12N2
• Molecular Weight: 136.19428
• Product Categories: PYRIDINE
• Mol File: 566155-76-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 236.847 °C at 760 mmHg
• Flash Point: 117.673 °C
• Appearance: /
• Density: 0.998 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-PYRIDINEMETHANAMINE, ALPHA,ALPHA-DIMETHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PYRIDINEMETHANAMINE, ALPHA,ALPHA-DIMETHYL-(566155-76-8)
• EPA Substance Registry System: 4-PYRIDINEMETHANAMINE, ALPHA,ALPHA-DIMETHYL-(566155-76-8)

Safety Data

• Hazardous Substances Data: 566155-76-8(Hazardous Substances Data)

Usage

General Description

4-Pyridinemethanamine, alpha,alpha-dimethyl- is an organic chemical compound with the molecular formula C8H12N2. It is a derivative of pyridine and is commonly used in the synthesis of pharmaceuticals and agrochemicals. 4-PYRIDINEMETHANAMINE, ALPHA,ALPHA-DIMETHYL- is known for its strong odor and is considered to be hazardous if not handled properly. It is also used as a reagent in various chemical reactions and is a common building block in the production of a wide range of organic compounds. Additionally, it is used in the manufacturing of dyes, pigments, and other specialty chemicals. Overall, 4-pyridinemethanamine, alpha,alpha-dimethyl- is a versatile and important chemical compound with various industrial applications.

Upstream product

• 100-48-1 pyridine-4-carbonitrile 
• 917-54-4 methyllithium 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1539276-43-1 N-[(1S,2R)-1-benzyl-2-hydroxy-3-(1-methyl-1-pyridin-4-ylethylamino)propyl]-5-piperidin-1-yl-N',N'-dipropylisophthalamide 

Relevant articles and documents

3-(1-OXO-5-(PIPERIDIN-4-YL)ISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure provides a compound of Formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, R3, Rx, and n are as defined herein, and methods of making and using same.

Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit

Antimalarial hit 1SR (TCMDC-134674) identified in a GlaxoSmithKline cell based screening campaign was evaluated for inhibitory activity against the digestive vacuole plasmepsins (Plm I, II, and IV). It was found to be a potent Plm IV inhibitor with no selectivity over Cathepsin D. A cocrystal structure of 1SR bound to Plm II was solved, providing structural insight for the design of more potent and selective analogues. Structure-guided optimization led to the identification of structurally simplified analogues 17 and 18 as low nanomolar inhibitors of both, plasmepsin Plm IV activity and P. falciparum growth in erythrocytes.

PYRIDAZINONE DERIVATIVES AND USE THEREOF AS P2X7 RECEPTOR INHIBITORS

Novel pyridazinone compounds of formula (I), which inhibit the purinergic P2X7 receptor and are useful for prevention, therapy and improvement of inflammatory and immunological diseases.