56633-51-3Relevant articles and documents
Process for the production of n-formyl-aspartyl-phenylalanine or its methyl ester
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, (2008/06/13)
A process for producing N-formyl-aspartylphenylalanine or its methyl ester, wherein aspartic acid is reacted with formic acid and acetic anhydride in approximately stoichiometric quantities in the presence or absence of a catalyst and phenylalanine or its methyl ester is directly added to the dehydration mixture. This process has a higher yield of the desired N-formyl-dipeptide and minimizes the amount of by-products and unreacted starting materials.
Process for producing α-L-aspartyl-L-phenylalanine methyl ester
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, (2008/06/13)
A process for preparing an α-L-aspartyl-L-phenylalanine methyl ester which comprises the steps of reacting formyl-L-aspartic anhydride with L-phenylalanine in the presence of water at a high pH, to produce formyl-α-L-aspartyl-L-phenylalanine; removing the formyl group from the formyl-α-L-aspartyl-L-phenylalanine and esterifying the resultant compound with methanol and hydrogen chloride to produce the hydrogen chloride salt of α-L-aspartyl-L-phenylalanine methyl ester; neutralizing the hydrogen chloride salt of α-L-aspartyl-L-phenylalanine methyl ester; and filtering the neutralized solution to produce α-L-aspartyl-L-phenylalanine methyl ester.
