56636-80-7

Basic information

• Product Name: Benzene, 1-[(1,1-dimethylethoxy)methyl]-4-methoxy-
• CAS NO: 56636-80-7
• Molecular Formula: C12H18O2
• Molecular Weight: 194.274
• Mol File: 56636-80-7.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: Benzene, 1-[(1,1-dimethylethoxy)methyl]-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-[(1,1-dimethylethoxy)methyl]-4-methoxy-(56636-80-7)
• EPA Substance Registry System: Benzene, 1-[(1,1-dimethylethoxy)methyl]-4-methoxy-(56636-80-7)

Safety Data

• Hazardous Substances Data: 56636-80-7(Hazardous Substances Data)

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 75-65-0 tert-butyl alcohol 
• 105-13-5 4-Methoxybenzyl alcohol 
• 151484-28-5 1,1-dimethylethyl diphenylphosphinite 
• 123-11-5 4-methoxy-benzaldehyde 
• 1616487-09-2 4-methoxybenzyl N-allyl thiocarbamate 
• 104-21-2 p-methoxybenzyl acetate 
• 866124-70-1 p-methoxybenzyloxydiphenylphosphine 
• 888071-72-5 N'-[(1E)-(4-methoxyphenyl)methylene]-4-methylbenzenesulfonohydrazide 
• 17988-20-4 (4-methoxy-benzyl)-trimethyl-silane 
• 180259-48-7 1-methoxy-4-((pent-4-en-1-yloxy)methyl)benzene 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 40156-88-5 p-methoxybenzyl diethyl phosphate 
• 71017-75-9 1-(4-methoxybenzyl)-2,4,6-triphenylpyridin-1-ium tetrafluoroborate salt 

Downstream Products

• 5405-95-8 4,4'-dimethoxydibenzyl ether 
• 833-79-4 t-butyl 4-methoxybenzoate 
• 123-11-5 4-methoxy-benzaldehyde 
• 105-13-5 4-Methoxybenzyl alcohol 
• 121-98-2 methyl 4-methoxybenzoate 
• 1515-81-7 1-methoxy-4-(methoxymethyl)benzene 
• 1449315-77-8 tert-butyl (tert-butylperoxy)(4-methoxyphenyl)methyl ether 
• 120157-94-0 N-(tert-butoxycarbonyl)p-methoxybenzylamine 

Relevant articles and documents

Auto-Tandem Catalysis with Frustrated Lewis Pairs for Reductive Etherification of Aldehydes and Ketones

Herein we report that a single frustrated Lewis pair (FLP) catalyst can promote the reductive etherification of aldehydes and ketones. The reaction does not require an exogenous acid catalyst, but the combined action of FLP on H2, R-OH or H2O generates the required Br?nsted acid in a reversible, “turn on” manner. The method is not only a complementary metal-free reductive etherification, but also a niche procedure for ethers that would be either synthetically inconvenient or even intractable to access by alternative synthetic protocols.

Gold(I)-catalyzed synthesis of unsymmetrical ethers using alcohols as alkylating reagents

A microwave-irradiated alcohol-protecting strategy based on gold catalysis utilizing benzyl alcohol, tert-butyl alcohol and triphenylmethanol as alkylating reagents has been developed. This protecting strategy has wide functional group tolerance with satisfactory yields for the majority of the selected alcohols. The mechanism of this transformation was probed with oxygen-18 isotope labelled alcohols assisted by GC-MS techniques and chemical kinetic experiments. This strategy provides an efficient, straightforward and alternative approach to the preparation of benzyl, tert-butyl and trityl ethers in organic synthesis.

Proton-exchanged montmorillonite-mediated reactions of methoxybenzyl esters and ethers

Proton-exchanged montmorillonite (H-mont) was found to be an eco-friendly and cost-effective catalyst for the generation of O-methylated quinone methides (QM) from the corresponding p or o-methoxybenzyl esters and ethers. Nucleophilic trapping of the O-methylated QM with arenes, alcohols, 1,3-dicarbonyl compounds, silyl enol ethers, and allylsilanes has been carried out, respectively, leading to eco-friendly benzylation reactions. Using this protocol, H-mont-mediated deprotection of PMB-protected esters and ethers have been realized for the first time. This work would pave the way for further exploration in O-alkylated QM that are of chemical and biological significance.