56644-06-5

Basic information

• Product Name: 1-CHLORO-6-PHENYLHEXANE
• Synonyms: 6-PHENYL-N-HEXYLCHLORIDE;6-PHENYLHEXYLCHLORIDE;(6-CHLOROHEXYL)BENZENE;1-CHLORO-6-PHENYLHEXANE
• CAS NO: 56644-06-5
• Molecular Formula: C₁₂H₁₇Cl
• Molecular Weight: 196.72
• Product Categories: Aromatics
• Mol File: 56644-06-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-CHLORO-6-PHENYLHEXANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CHLORO-6-PHENYLHEXANE(56644-06-5)
• EPA Substance Registry System: 1-CHLORO-6-PHENYLHEXANE(56644-06-5)

Safety Data

• Hazardous Substances Data: 56644-06-5(Hazardous Substances Data)

Usage

Description

1-CHLORO-6-PHENYLHEXANE, also known as 6-Phenylhexylchloride (CAS# 56644-06-5), is a light yellow oil with chemical properties that make it a valuable compound in the field of organic synthesis. It is characterized by its unique molecular structure, which includes a chloro group attached to a hexane chain with a phenyl group at the sixth position.

Uses

1. Used in Organic Synthesis:
1-CHLORO-6-PHENYLHEXANE is used as a synthetic intermediate for the production of various organic compounds. Its application in this field is due to its versatile chemical properties, which allow it to be easily modified and incorporated into more complex molecules.
2. Used in Pharmaceutical Industry:
1-CHLORO-6-PHENYLHEXANE is used as a building block for the development of new pharmaceutical compounds. Its unique structure and reactivity make it a promising candidate for the creation of novel drugs with potential therapeutic applications.
3. Used in Chemical Research:
1-CHLORO-6-PHENYLHEXANE serves as a valuable research tool in the field of chemistry, particularly in the study of reaction mechanisms and the development of new synthetic methods. Its light yellow oil form and chemical properties make it an ideal subject for various experimental procedures.
4. Used in Material Science:
1-CHLORO-6-PHENYLHEXANE can be utilized in the development of new materials with specific properties, such as improved stability, reactivity, or selectivity. Its unique molecular structure and chemical properties make it a valuable component in the design and synthesis of advanced materials for various applications.

Upstream product

• 2430-16-2 6-phenyl-1-hexanol 
• 2163-00-0 1,6-dichlorohexane 
• 71-43-2 benzene 
• 591-50-4 iodobenzene 
• 6294-17-3 1-bromo-6-chlorohexane 
• 5581-76-0 6-phenyl-hexanoic acid methyl ester 
• 54723-26-1 methyl 6-phenyl-5-oxohexanoate 
• 2009-83-8 6-chloro-1-hexanol 
• 5123-13-7 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane 
• 71042-21-2 4-methylbenzenesulfonic acid 6-chlorohexyl ester 
• 98-80-6 phenylboronic acid 
• 23418-91-9 9-phenyl-9-borabicyclo[3.3.1]nonane 
• 100-59-4 phenylmagnesium chloride 
• 87100-28-5 pinacol benzylboronate 

Downstream Products

• 39520-64-4 7-phenylheptanenitrile 
• 84831-59-4 2,5-Dimethyl-4-(5-phenyl-pentyl)-2H-pyrazol-3-ylamine 
• 84831-55-0 2-Acetyl-7-phenyl-heptanenitrile 
• 84831-64-1 5-Isocyanato-1,3-dimethyl-4-(5-phenyl-pentyl)-1H-pyrazole 
• 84831-72-1 [2,5-Dimethyl-4-(5-phenyl-pentyl)-2H-pyrazol-3-yl]-urea 
• 178980-18-2 5-(3,5-dichlorophenylthio)-2-hydroxymethyl-4-isopropyl-1-(6-phenylhexyl)-1H-imidazole 
• 164979-31-1 5-methyl-2-(6-phenylhexyloxy)-1,3-benzenedicarboxaldehyde 
• 164979-15-1 4-(6-phenylhexyloxy)-1,3-benzenedicarboxaldehyde 
• 138619-78-0 2-(6-phenylhexyl)-1,3-dihydro-1,3-dioxo-2H-isoindole 
• 1077-16-3 hexylbenzene 
• 17734-20-2 6-phenylhexylamine 

Relevant articles and documents

Transition Metal-Free sp3?sp3 Carbon-Carbon Coupling between Benzylboronic Esters and Alkyl Bromides

A transition metal-free coupling reaction of benzylboronic esters and alkyl halides has been developed. Both alkyl bromides and alkyl iodides were found to be competent substrates with the nucleophilic boronate intermediate generated from the combination of benzylboronic ester and an alkyllithium. Good chemoselectivity was observed for the reaction with the alkyl bromide in substrates with a second electrophile present. Both secondary and tertiary benzylboronic esters were effective nucleophiles in the reaction with primary alkyl halides. Mechanistic observations are consistent with a radical mechanism.

Synthesis of N-ω-phenylalkyl-4-(p-chlorophenyl)-piperidin-4-ol analogues with potent antiproliferative activity against HCT-116 cells

Some opioid analogues, such as morphine and loperamide, were reported to exhibit weak antiproliferative activity against tumor cells. In a study of loperamide analogues, we found that adding an N-ω-phenylalkyl group onto the 4-arylpiperidin-4-ol unit can have important effects on the antiproliferative activity of such compounds against HCT-116 cells. We optimized the distance between the phenyl group and 4-arylpiperidin unit to promote such activity.

Suzuki-miyaura cross-coupling reactions of unactivated alkyl halides catalyzed by a nickel pincer complex

A nickel(II) pincer complex, [(MeN2N)Ni-Cl], was used to catalyze alkyl-alkyl and alkyl-aryl Suzuki-Miyaura coupling reactions of unactivated alkyl halides. The coupling of 9-alkyl-9-borabicyclo[3.3.1]nonane and 9-phenyl-9-borabicyclo[3.3.1]nonane reagents with alkyl halides was achieved in modest to good yields. The reactions tolerated a variety of useful functional groups including ester, ether, furan, thioether, acetal, and Boc groups. Georg Thieme Verlag Stuttgart, New York.