56658-05-0

Basic information

• Product Name: Benzamide, 2-bromo-N-(2-hydroxy-1,1-dimethylethyl)-5-methoxy-
• CAS NO: 56658-05-0
• Molecular Formula: C12H16BrNO3
• Molecular Weight: 302.16400
• Mol File: 56658-05-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzamide, 2-bromo-N-(2-hydroxy-1,1-dimethylethyl)-5-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 2-bromo-N-(2-hydroxy-1,1-dimethylethyl)-5-methoxy-(56658-05-0)
• EPA Substance Registry System: Benzamide, 2-bromo-N-(2-hydroxy-1,1-dimethylethyl)-5-methoxy-(56658-05-0)

Safety Data

• Hazardous Substances Data: 56658-05-0(Hazardous Substances Data)

Upstream product

• 22921-68-2 2-bromo-5-methoxy-benzoic acid 
• 56658-04-9 2-bromo-5-methoxybenzoyl chloride 
• 124-68-5 2-Amino-2-methyl-1-propanol 

Downstream Products

• 60081-44-9 4-[2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-4-methoxy-phenyl]-1-methyl-piperidin-4-ol 
• 744995-13-9 1-benzyl-4-[2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-4-methoxy-phenyl]-piperidin-4-ol 
• 60081-45-0 1'-benzyl-5-methoxy-spiro[isobenzofuran-1,4'-piperidin]-3-one 
• 866526-30-9 4,5-dihydro-4,4-dimethyl-2-(5-methoxy-2-(diphenylphosphino)phenyl)oxazole 
• 56658-06-1 2-(2-bromo-5-methoxy-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 

Relevant articles and documents

C-H to C-N Cross-Coupling of Sulfonamides with Olefins

Cross-coupling of nitrogen with hydrocarbons under fragment coupling conditions stands to significantly impact chemical synthesis. Herein, we disclose a C(sp3)-N fragment coupling reaction between terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/SOX (sulfoxide-oxazoline) catalyzed intermolecular allylic C-H amination. A range of (56) allylic amines are furnished in good yields (avg. 75%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). Mechanistic studies reveal that the SOX ligand framework is effective at promoting functionalization by supporting cationic π-allyl Pd.