567-15-7

Basic information

• Product Name: 1-(trifluoromethyl)-2-[2-(trifluoromethyl)phenyl]benzene
• Synonyms: 1-(trifluoromethyl)-2-[2-(trifluoromethyl)phenyl]benzene;2,2'-Bis-(trifluoromethyl)biphenyl
• CAS NO: 567-15-7
• Molecular Formula: C₁₄H₈F₆
• Molecular Weight: 290.21
• Mol File: 567-15-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 32 °C
• Boiling Point: 293.3 °C at 760 mmHg
• Flash Point: 101.8 °C
• Appearance: /
• Density: 1.308 g/cm³
• CAS DataBase Reference: 1-(trifluoromethyl)-2-[2-(trifluoromethyl)phenyl]benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(trifluoromethyl)-2-[2-(trifluoromethyl)phenyl]benzene(567-15-7)
• EPA Substance Registry System: 1-(trifluoromethyl)-2-[2-(trifluoromethyl)phenyl]benzene(567-15-7)

Safety Data

• Hazardous Substances Data: 567-15-7(Hazardous Substances Data)

Usage

General Description

1-(trifluoromethyl)-2-[2-(trifluoromethyl)phenyl]benzene, also known as 1,2-bis(2-(trifluoromethyl)phenyl)-1,1,2,2-tetrafluoroethane, is a chemical compound with the molecular formula C15H9F6. It is a white crystalline solid that is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. 1-(trifluoromethyl)-2-[2-(trifluoromethyl)phenyl]benzene is characterized by its trifluoromethyl and phenyl groups, which contribute to its unique properties and reactivity. 1-(trifluoromethyl)-2-[2-(trifluoromethyl)phenyl]benzene is widely used in organic synthesis and is a valuable intermediate for the production of various chemical compounds. It is important to handle this compound with care and follow proper safety protocols due to its potential hazards and reactivity.

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 88-16-4 1-chloro-2-(trifluoromethyl)benzene 
• 578-57-4 2-bromoanisole 
• 95-56-7 2-hydroxybromobenzene 
• 1003-31-2 thiophene-2-carbonitrile 
• 444-29-1 2-iodo(trifluoromethyl)benzene 
• 392-83-6 o-trifluoromethylphenyl bromide 
• 76644-52-5 rac-3-acetoxycyclohexene 
• 31268-20-9 bromomethyl phenyl sulfoxide 
• 1423-27-4 2-(trifluoromethyl)phenylboronic acid 

Relevant articles and documents

Palladium-catalyzed reaction of boronic acids with chiral and racemic α-bromo sulfoxides

Palladium-catalyzed cross-coupling reactions of racemic α-bromo sulfoxides with boronic acids are carried out in either aqueous or nonaqueous medium with formation of a new C sp3-C sp2 bond. The arylation of chiral α-bromo sulfoxides occurs without racemization. The cross-coupling reaction is general and gives high yields with arylboronic acids substituted with either donor or acceptor groups but gives poor results with heteroarylboronic acids. The best yields are obtained using degassed solvents and CsF instead of aqueous base. The use of aqueous base and the presence of oxygen favor the homocoupling side reaction.

Homocoupling of aryl iodides and bromides promoted by sulfur-containing palladacycles

Sulfur-containing palladacycles, in particular those derived from the orthometalation of benzylthioethers, effectively promote the homocoupling of aryl iodides and bromides, under relatively mild reaction conditions to furnish symmetrical biphenyls in good yields.

Activation of Reducing Agents. Sodium Hydride Containing Complex Reducing Agents. 32. NiCRAL's as Very Efficient Agents in Promoting Cross-Coupling of Aryl Halides

Nickel-containing complex reducing agents NiCRA-bpy are shown to be the first nickel reagents able to efficiently perform cross-coupling of aryl halides.The presence of KI in the reaction medium generally improves the procedure.The mechanism and influence of the structures of the substrates are discused.