567-62-4

Basic information

• Product Name: Benzoic acid, 2-amino-6-hydroxy-
• Synonyms: Benzoic acid, 2-amino-6-hydroxy-;2-Amino-6-hydroxybenzoic acid;6-Aminosalicylic acid;6-Hydroxyanthranilic acid
• CAS NO: 567-62-4
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 153.14
• Mol File: 567-62-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 148℃
• Boiling Point: 352.2±32.0 °C(Predicted)
• Appearance: /
• Density: 1.491
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 3.30±0.25(Predicted)
• CAS DataBase Reference: Benzoic acid, 2-amino-6-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-amino-6-hydroxy-(567-62-4)
• EPA Substance Registry System: Benzoic acid, 2-amino-6-hydroxy-(567-62-4)

Safety Data

• Hazardous Substances Data: 567-62-4(Hazardous Substances Data)

Usage

General Description

Benzoic acid, 2-amino-6-hydroxy- is a chemical compound with the molecular formula C7H7NO3. Also known as salicylamin, it is a derivative of salicylic acid and is used in the production of pharmaceuticals and as a biochemical reagent. It is a white crystalline solid with a melting point of 140-142°C and is soluble in water and ethanol. Benzoic acid, 2-amino-6-hydroxy- has antibacterial and antifungal properties and is commonly used in the preservation of food and beverages. It is also used as an intermediate in the synthesis of other organic compounds and as a precursor to the production of dyes and pigments.

Upstream product

• 601-99-0 2-hydroxy-6-nitrobenzoic acid 
• 53600-33-2 6-methoxyanthranilic acid 
• 60144-52-7 tert-butyl 3-methoxyphenylcarbamate 
• 536-90-3 m-Anisidine 
• 136247-94-4 N-(tert-butoxycarbonyl)-6-methoxyanthranilic acid 
• 55289-35-5 2-bromo-6-nitrotoluene 
• 5344-49-0 2-chloro-6-nitrobenzoic acid 
• 72106-43-5 2-hydroxy-6-nitrobenzonitrile 
• 38876-67-4 2-bromo-6-nitrobenzoic acid 
• 76093-21-5 2-nitro-6-phenoxybenzoic acid 
• 408337-50-8 2-(2,4-dinitro-phenoxy)-6-nitro-benzoic acid 

Downstream Products

• 90873-81-7 6-amino-3-(α-amino-isopropyl)-2-hydroxy-benzoic acid 
• 100801-09-0 2-amino-6-hydroxy-benzoic acid ; 4-amino-4-methyl-pentan-2-one salt 
• 94501-73-2 6-amino-3-(1-amino-1-methyl-heptyl)-2-hydroxy-benzoic acid 
• 92577-53-2 6-amino-3-(1-amino-1-methyl-propyl)-2-hydroxy-benzoic acid 
• 118-48-9 5-hydroxyisatoic acid 
• 195986-91-5 6-hydroxy-1,2-dihydro-4H-3,1-benzoxazin-2,4-dione 
• 1393714-23-2 13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl(3-methoxyphenyl) carbamate 
• 1393714-24-3 13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl o-tolylcarbamate 
• 1393714-25-4 13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[1,2-b]quinazolin-10-yl(4-isopropylphenyl) carbamate 
• 85654-22-4 2-hydroxy-7,8-dihydro-6H,11H-pyrrolo[2,1-b]quinazolin-11-one 
• 929859-22-3 7-(benzyloxy)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one 
• 1393714-38-9 7-(benzyloxy)-4-methyl-9-oxo-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-4-ium iodide 
• 1393714-39-0 7-(benzyloxy)-1,2,3,3a,4,9-hexahydro-4-methylpyrrolo[2,1-b]quinazoline 
• 1393714-29-8 4-methyl-1,2,3,3a,4,9-hexahydropyrrolo[2,1-b]quinazolin-7-yl (3-methoxyphenyl)carbamate 

Relevant articles and documents

Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections

Targeting PqsD is a promising novel approach to disrupt bacterial cell-to-cell-communication in Pseudomonas aeruginosa. In search of selective PqsD inhibitors, two series of benzamidobenzoic acids - one published as RNAP inhibitors and the other as PqsD inhibitors - were investigated for inhibitory activity toward the respective other enzyme. Additionally, novel derivatives were synthesized and biologically evaluated. By this means, the structural features needed for benzamidobenzoic acids to be potent and, most notably, selective PqsD inhibitors were identified. The most interesting compound of this study was the 3-Cl substituted compound 5 which strongly inhibits PqsD (IC 50 6.2 μM) while exhibiting no inhibition of RNAP.