5680-83-1

Basic information

• Product Name: CBZ-GLY HYDRAZIDE
• Synonyms: N-CBZ-GLYCINE HYDRAZIDE;CBZ-GLY HYDRAZIDE;(N-benzyloxycarbonylglycyl)hydrazine;benzyl (hydrazinocarbonylmethyl)carbamate;CBZ-GLYCINE HYDRAZIDE;N-[(Benzyloxy)carbonyl]glycine hydrazide;N-(2-hydrazino-2-keto-ethyl)carbamic acid benzyl ester;phenylmethyl N-(2-hydrazinyl-2-oxoethyl)carbamate
• CAS NO: 5680-83-1
• Molecular Formula: C₁₀H₁₃N₃O₃
• Molecular Weight: 223.23
• EINECS: 227-141-2
• Mol File: 5680-83-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 116-117 °C
• Boiling Point: 491.6 °C at 760 mmHg
• Flash Point: 251.1 °C
• Appearance: /
• Density: 1.259 g/cm³
• Vapor Pressure: 8.25E-10mmHg at 25°C
• Refractive Index: 1.563
• PKA: 11.19±0.46(Predicted)
• CAS DataBase Reference: CBZ-GLY HYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CBZ-GLY HYDRAZIDE(5680-83-1)
• EPA Substance Registry System: CBZ-GLY HYDRAZIDE(5680-83-1)

Safety Data

• Hazardous Substances Data: 5680-83-1(Hazardous Substances Data)

Usage

General Description

CBZ-GLY HYDRAZIDE, also known as carboxybenzyl-glycine hydrazide, is a chemical compound used in the synthesis of pharmaceuticals and organic compounds. It is a hydrazide derivative of glycine which has been found to have antibacterial and antifungal properties. CBZ-GLY HYDRAZIDE has been studied for its potential use in the treatment of various diseases and conditions, including cancer and infectious diseases. Its chemical structure and functional groups make it a versatile building block for the synthesis of new drugs and biologically active compounds. Additionally, it has shown potential for use in the field of materials science and catalysis due to its unique molecular properties. Overall, CBZ-GLY HYDRAZIDE is a valuable chemical with diverse applications in pharmaceutical, biological, and materials science research.

InChI:InChI=1/C10H13N3O3/c11-13-9(14)6-12-10(15)16-7-8-4-2-1-3-5-8/h1-5H,6-7,11H2,(H,12,15)(H,13,14)

Upstream product

• 1212-53-9 methyl N-benzyloxycarbonylglycinate 
• 1145-81-9 ethyl 2-(benzyloxycarbonylamino)ethanoate 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 6154-42-3 Carbobenzoxyglycin-m-nitrophenylester 
• 64-17-5 ethanol 
• 7803-57-8 hydrazine hydrate 
• 173459-80-8 benzyl [2?(1H?benzo[d][1,2,3]triazol?1?yl)?2?oxoethyl]carbamate 
• 23776-82-1 tert-butyl 2-(((benzyloxy)carbonyl)glycyl)hydrazine-1-carboxylate 

Downstream Products

• 23262-07-9 Cbz-glycylalanine ethyl ester 
• 50622-95-2 benzyl (2-azido-2-oxoethyl)carbamate 
• 35180-85-9 N-(N-benzyloxycarbonyl-glycyl)-alanine benzyl ester 
• 64532-71-4 Z-Gly-D-Ala-OEt 
• 3069-69-0 (5-oxo-4,5-dihydro-[1,3,4]oxadiazol-2-ylmethyl)-carbamic acid benzyl ester 
• 83387-95-5 Cbz-glycylvalyl hydrazide 
• 101587-22-8 Benzyloxycarbonyl-glycyl-iminodiessigsaeure-dimethylester 
• 3069-73-6 ω-(Z-Glycyl)-hydrazin-dicarbonsaeure-ω'-(glycinethylester)-amid; 'Z-Glycyl-azaglycyl-azaglycyl'-glycin-ethylester 
• 96447-73-3 N-(benzyloxycarbonyl)glycyl-azaglycine-amide 
• 96652-98-1 Z-Glycyl-glycin-semicarbazid 
• 5879-49-2 N-Benzyloxycarbonyl-glycyl-glycin-(2-methylmercapto-ethylester) 
• 113398-28-0 {[3,5-Bis-(benzyloxycarbonylamino-methyl)-[1,2,4]triazol-4-ylcarbamoyl]-methyl}-carbamic acid benzyl ester 
• 77437-38-8 ethyl 4,6-O-benzylidene-2-<(N-Z-glycyl)-amino>-2-deoxy-D-gluconate 
• 54321-69-6 [(6-Chloro-4-hydroxy-2-methyl-4-phenyl-4H-quinazolin-3-ylcarbamoyl)-methyl]-carbamic acid benzyl ester 

Relevant articles and documents

An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds

Herein, we describe the development of a simple, high yielding and stereocontrolled strategy for the synthesis of a series of triazolopiperazines and other biologically relevant fused scaffolds from optically active amino acids. This route was applied to the synthesis of 22 scaffolds containing new, previously inaccessible vectors and used to access a novel analogue of ganaplacide.

Oxadiazole-Based Cell Permeable Macrocyclic Transition State Inhibitors of Norovirus 3CL Protease

Human noroviruses are the primary causative agents of acute gastroenteritis and a pressing public health burden worldwide. There are currently no vaccines or small molecule therapeutics available for the treatment or prophylaxis of norovirus infections. Norovirus 3CL protease plays a vital role in viral replication by generating structural and nonstructural proteins via the cleavage of the viral polyprotein. Thus, molecules that inhibit the viral protease may have potential therapeutic value. We describe herein the structure-based design, synthesis, and in vitro and cell-based evaluation of the first class of oxadiazole-based, permeable macrocyclic inhibitors of norovirus 3CL protease.

Benzotriazole-mediated synthesis of aza-peptides: En route to an aza-leuenkephalin analogue

Novel N-(N-Pg-azadipeptidoyl)benzotriazoles 20a-e couple efficiently with α-amino acids 21a-e, dipeptides 22a-c, aminoxyacetic acid 23a, depsidipeptide 23b, and α-hydroxy-β-phenylpropionic acid 27 yielding, respectively, azatripeptides 24a-g, azatetrapeptides 25a,b, a hybrid azatripeptide with an oxyamide bond 26a, a hybrid azatetrapeptide with an ester bond 26b, and a hybrid azatripeptide with an ester bond 28. A new protocol for the synthesis of N-Pg-azatripeptides 33a,b and 35a,b, each containing a natural amino acid at the N-terminus, avoids the low coupling rates of the aza-amino acid residue and enables the solution-phase synthesis of an azaphenylalanine analogue of Leu-enkephalin 40.