56836-94-3Relevant articles and documents
Environment-friendly non-toxic synthesis method of clenbuterol hydrochloride
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Paragraph 0032; 0050-0053, (2020/07/21)
The invention provides an environment-friendly non-toxic synthesis method of clenbuterol hydrochloride. The synthesis method comprises the following steps: 1) preparing an intermediate 1; 2) preparingan intermediate 2; 3) preparing clenbuterol; and 4) preparing the clenbuterol hydrochloride. The synthesis method comprises the following steps: synthesizing an intermediate 1 by adopting an oxidation method; and then forming a Schiff base intermediate 2 with tert-butylamine, and then preparing clenbuterol by reduction so that the condition that an alpha-bromo-structure intermediate with genotoxicity is prepared by using liquid bromine or other brominating agents in a traditional production process is avoided, the new synthesis method is environment-friendly and non-toxic, and the clinical use risk of clenbuterol hydrochloride is effectively reduced.
Secondary amines, their preparation and use in pharmaceutical compositions
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, (2008/06/13)
The compounds of the formula (II): STR1 and their pharmaceutically acceptable salts wherein R1 is a hydrogen, fluorine or chlorine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, ureido, trifluoromethyl or p-methoxybenzylamino group; R2 is a hydrogen, fluorine or chlorine atom or a hydroxyl group; R3 is a hydrogen or chlorine atom or a hydroxyl group; R4 is a carboxylic acid group or a salt, ester or amide thereof; R5 is a hydrogen, chlorine or fluorine atom or a methyl, methoxyl or hydroxyl group or a carboxylic acid group or a salt, ester or amide thereof; R6 is a hydrogen atom or a methyl, or propyl group; X is an oxygen atom or a bond; and Y is an alkylene group of up to 6 carbon atoms or a bond have been found to possess anti-obesity and/or antihyperglycaemic activity.
1-Phenyl-2-aminoethanol derivatives
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, (2008/06/13)
The invention concerns new topical anti-inflammatory 1-phenyl-2-aminoethanol derivatives of the general formula: wherein R1 is a phenyl bearing specific combinations of (2-12C)alkanoyloxy,[(2-12C)alkanoyloxy]methyl,chloro and amino substituents