5685-38-1

Basic information

• Product Name: 2-PHENYL-CYCLOPROPANECARBOXYLIC ACID
• Synonyms: AKOS B022610;AKOS MSC-0115;2-PHENYL-CYCLOPROPANECARBOXYLIC ACID;TIMTEC-BB SBB003944;Nsc245855;1-Carboxy-2-phenylcyclopropane, (2-Carboxycycloprop-1-yl)benzene;1-Carboxy-2-phenylcyclopropane;2-Phenyl-1-cyclopropanecarboxylic acid
• CAS NO: 5685-38-1
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.19
• Mol File: 5685-38-1.mol
• Article Data: 25

Chemical Properties

• Melting Point: 89-90 °C(Solv: water (7732-18-5))
• Boiling Point: 317.1±31.0 °C(Predicted)
• Appearance: /
• Density: 1.250±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.57±0.10(Predicted)
• CAS DataBase Reference: 2-PHENYL-CYCLOPROPANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-CYCLOPROPANECARBOXYLIC ACID(5685-38-1)
• EPA Substance Registry System: 2-PHENYL-CYCLOPROPANECARBOXYLIC ACID(5685-38-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 5685-38-1(Hazardous Substances Data)

Usage

General Description

2-Phenyl-cyclopropanecarboxylic acid is a chemical compound with the molecular formula C10H10O2. It is a white crystalline powder, often used in the synthesis of pharmaceuticals and other organic compounds. This chemical is known for its stable and non-reactive nature, making it suitable for use as an intermediate in organic synthesis. It is also used as an intermediate in the preparation of other complex compounds, and its unique cyclopropane ring structure gives it interesting properties for medical and chemical research. Its potential applications make it a valuable compound in the field of organic chemistry.

Upstream product

• 201230-82-2 carbon monoxide 
• 3234-51-3 1,1-dibromo-2-phenylcyclopropane 
• 946-38-3 ethyl 2-phenylcyclopropylcarboxylate 
• 474955-43-6 l-menthyl 2-phenylcyclopropanecarboxylate 
• 20030-70-0 methyl 2-phenylcyclopropane-1-carboxylate 
• 100-52-7 benzaldehyde 
• 4610-69-9 (Z)-ethyl cinnamate 
• 75-11-6 diiodomethane 
• 140-10-3 cis-cinnamic acid 
• 67074-44-6 trans-2-phenyl-1-cyclopropanecarbaldehyde 
• 4192-77-2 ethyl cinnamate 
• 97-71-2 (1R,2R)-2-phenyl-cyclopropanecarboxylic acid ethyl ester 
• 63106-93-4 (1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one 
• 936-98-1 ((R)-2-Phenyl-cyclopropyl)-methanol 

Downstream Products

• 67528-62-5 cis-methyl 2-phenylcyclopropane-1-carboxylate 
• 4659-85-2 2-hhenylcyclopropane-1-carboxamide 
• 939-87-7 2-phenyl-1-cyclopropanecarbonyl chloride 
• 4186-30-5 cis-N-Ethyl-2-phenylcyclopropanecarboxamide 
• 3977-92-2 cis-2-phenylcyclopropanecarboxylic acid diethylamide 
• 20030-70-0 methyl 2-phenylcyclopropane-1-carboxylate 
• 5682-61-1 (1S,2S)-2-phenylcyclopropanecarboxylic acid methyl ester 
• 5682-61-1 (1S,2R)-2-phenylcyclopropanecarboxylic acid methyl ester 
• 100468-15-3 2-Phenyl-cyclopropanecarboxylic acid (3-imidazol-1-yl-propyl)-amide 
• 946-39-4 ethyl rac-(1S,2S)-2-phenylcycloproanecarboxylate 
• 61826-40-2 (2-phenylcyclopropyl)methanol 
• 105367-36-0 (1R)-menthyl (1S,2S)-(+)-2-phenylcyclopropanecarboxylate 
• 105367-37-1 (1S,2R)-l-menthyl 2-phenylcyclopropane-1-carboxylate 
• 1008-76-0 4,5-dihydro-5-phenyl-2(3H)-furanone 

Relevant articles and documents

A de novo peroxidase is also a promiscuous yet stereoselective carbene transferase

By constructing an in vivo-assembled, catalytically proficient peroxidase, C45, we have recently demonstrated the catalytic potential of simple, de novo-designed heme proteins. Here, we show that C45's enzymatic activity extends to the efficient and stereoselective intermolecular transfer of carbenes to olefins, heterocycles, aldehydes, and amines. Not only is this a report of carbene transferase activity in a completely de novo protein, but also of enzyme-catalyzed ring expansion of aromatic heterocycles via carbene transfer by any enzyme.

Nickel-Catalyzed Reductive Carboxylation of Cyclopropyl Motifs with Carbon Dioxide

A nickel-catalyzed reductive carboxylation technique for the synthesis of cyclopropanecarboxylic acids has been developed. This user-friendly and mild transformation operates at atmospheric pressure of carbon dioxide and utilizes either organic halides or alkene precursors, thus representing the first example of catalytic reductive carboxylation of secondary counterparts lacking adjacent π-components.

(HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS

The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.