56877-55-5

Basic information

• Product Name: N^α-(N-benzyloxycarbonyl-D-leucyl)-L-tryptophan-methyl ester
• Synonyms: N^α-(N-benzyloxycarbonyl-D-leucyl)-L-tryptophan-methyl ester
• CAS NO: 56877-55-5
• Molecular Weight: 465.549
• Mol File: 56877-55-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N^α-(N-benzyloxycarbonyl-D-leucyl)-L-tryptophan-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N^α-(N-benzyloxycarbonyl-D-leucyl)-L-tryptophan-methyl ester(56877-55-5)
• EPA Substance Registry System: N^α-(N-benzyloxycarbonyl-D-leucyl)-L-tryptophan-methyl ester(56877-55-5)

Safety Data

• Hazardous Substances Data: 56877-55-5(Hazardous Substances Data)

Upstream product

• 4703-53-1 N-benzyloxycarbonylleucinehydrazid 
• 4299-70-1 L-tryptophan methyl ester 
• 28862-79-5 Z-D-Leu-OH 
• 7524-52-9 (S)-tryptophan methyl ester hydrochloride 

Relevant articles and documents

Construction of Indole Structure on Pyrroloindolines via AgNTf2-Mediated Amination/Cyclization Cascade: Application to Total Synthesis of (+)-Pestalazine B

An N-linked indole structure was constructed on the 3a-position of pyrroloindoline derivatives via a cascade process involving silver-mediated amination of bromopyrroloindolines with 2-ethynylanilines with subsequent 5-endo-dig cyclization. In this reaction, AgNTf2 was used as a tandem reagent, which activated the bromo group as a σ-Lewis acid and the alkyne moiety as a π-Lewis acid. Switching from the initial step to the second step was conducted by controlling the temperature. This protocol was applied to the synthesis of various pyrroloindolines, α-carboline, and furoindolines and the total synthesis of a dimeric indole alkaloid, (+)-pestalazine B.