569-72-2

Basic information

• Product Name: 1-(2,2-DIFLUORO-1-PHENYL-VINYL)-4-FLUORO-BENZENE
• Synonyms: 1-(2,2-DIFLUORO-1-PHENYL-VINYL)-4-FLUORO-BENZENE
• CAS NO: 569-72-2
• Molecular Formula: C₁₄H₁₀F₂
• Molecular Weight: 234.2164696
• Product Categories: pharmacetical
• Mol File: 569-72-2.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 261.5°Cat760mmHg
• Flash Point: 97.6°C
• Appearance: /
• Density: 1.199g/cm³
• Vapor Pressure: 0.019mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: 1-(2,2-DIFLUORO-1-PHENYL-VINYL)-4-FLUORO-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2-DIFLUORO-1-PHENYL-VINYL)-4-FLUORO-BENZENE(569-72-2)
• EPA Substance Registry System: 1-(2,2-DIFLUORO-1-PHENYL-VINYL)-4-FLUORO-BENZENE(569-72-2)

Safety Data

• Hazardous Substances Data: 569-72-2(Hazardous Substances Data)

Usage

General Description

1-(2,2-Difluoro-1-phenyl-vinyl)-4-fluoro-benzene is a chemical compound with the molecular formula C14H8F3. It is a synthetic organic compound that consists of a benzene ring substituted with a vinyl group and two fluorine atoms at the 2nd and 2nd' positions, as well as a fluorine atom at the 4th position. 1-(2,2-DIFLUORO-1-PHENYL-VINYL)-4-FLUORO-BENZENE is primarily used in the field of organic synthesis and medicinal chemistry. It can be used as a building block for the synthesis of various pharmaceuticals and agrochemicals, and it also has potential applications as a fluorescent dye or a material for organic light-emitting diodes (OLEDs) due to its unique chemical structure. Additionally, it may also possess biological activity and be used as a research tool for understanding the molecular basis of certain diseases.

InChI:InChI=1/C14H9F3/c15-12-8-6-11(7-9-12)13(14(16)17)10-4-2-1-3-5-10/h1-9H

Upstream product

• 434-71-9 1-chloro-1,1-difluoro-2,2-diphenyl-ethane 
• 119-61-9 benzophenone 
• 2923-18-4 sodium 2,2,2-trifluoroacetate 
• 998-40-3 tributylphosphine 
• 6312-18-1 2-chloro-2,2-difluoro-1,1-diphenyl-ethanol 
• 420-32-6 thiocarbonyl fluoride 
• 908093-98-1 diazodiphenylmethane 
• 129932-29-2 difluoromethyl-diphenyl-phosphine oxide 
• 94993-99-4 diethyl difluoromethylphosphonate lithium salt 
• 75-45-6 Chlorodifluoromethane 
• 4214-38-4 (diphenylmethylene)triphenylphosphorane 
• 7333-65-5 (diphenylmethyl)triphenylphosphonium bromide 
• 24925-18-6 phenyl(trifluoromethyl)mercury 
• 1450-31-3 Thiobenzophenon 

Downstream Products

• 82947-11-3 2-methyl-6-(1-phenylbenzyl)-4H-pyran-4-one 
• 72837-38-8 1-(1-fluoro-2,2-diphenylvinyl)-1H-imidazole 
• 17822-21-8 2-(1-fluoro-2,2-diphenyl-vinyl)-benzothiazole 

Relevant articles and documents

Visible-light-promotedE-selective synthesis of α-fluoro-β-arylalkenyl sulfidesviathe deoxygenation/isomerization process

Regioselective synthesis of α-fluoro-β-arylalkenyl sulfides has been established withgem-difluoroalkenes and sodium sulfinates in a transition-metal-free manner. A series of control experiments were executed to demonstrate thiol radicals and anions as the proposed intermediates. Notably, regioselectiveZ→Eisomerization was achieved under green light irradiation in the absence of a photoinitiator.

From C1 to C3: Copper-Catalyzed gem-Bis(trifluoromethyl)olefination of α-Diazo Esters with TMSCF3

A Cu-catalyzed gem-bis(trifluoromethyl)olefination of α-diazo esters, using TMSCF3 as the only fluorocarbon source, has been developed and provides an exquisite method to access gem-bis(trifluoromethyl)alkenes. This unprecedented olefination pr

Direct α-Monofluoroalkenylation of Heteroatomic Alkanes via a Combination of Photoredox Catalysis and Hydrogen-Atom-Transfer Catalysis

In this study, a new C(sp3)-H monofluoroalkenylation reaction involving cooperative visible-light photoredox catalysis and hydrogen-atom-transfer catalysis to afford products generated by selective hydrogen abstraction and radical-radical cross-coupling was described. This mild, efficient reaction shows high regioselectivity for the α-carbon atoms of amines, ethers, and thioethers and thus allows the preparation of monofluoroalkenes bearing various substituents. The reaction was applied to two bioactive molecules, indicating its utility for late-stage monofluoroalkenylation of compounds with inert C(sp3)-H bonds.