56935-79-6

Basic information

• Product Name: 4-(3,5-Dimethyl-1H-pyrazol-1-yl)benzonitrile 97%
• Synonyms: 4-(3,5-Dimethyl-1H-pyrazol-1-yl)benzonitrile 97%;4-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)BENZONITRILE;1-(4-Cyanophenyl)-3,5-dimethyl-1H-pyrazole;4-(3,5-DiMethylpyrazol-1-yl)benzonitrile;4-(3,5-Dimethyl-1H-pyrazol-1-yl)benzonitrile97%
• CAS NO: 56935-79-6
• Molecular Formula: C₁₂H₁₁N₃
• Molecular Weight: 197.24
• Mol File: 56935-79-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 57-59°C
• Boiling Point: 343.3°Cat760mmHg
• Flash Point: 161.4°C
• Appearance: /
• Density: 1.1g/cm³
• Vapor Pressure: 7.12E-05mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 4-(3,5-Dimethyl-1H-pyrazol-1-yl)benzonitrile 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,5-Dimethyl-1H-pyrazol-1-yl)benzonitrile 97%(56935-79-6)
• EPA Substance Registry System: 4-(3,5-Dimethyl-1H-pyrazol-1-yl)benzonitrile 97%(56935-79-6)

Safety Data

• Hazardous Substances Data: 56935-79-6(Hazardous Substances Data)

Usage

General Description

4-(3,5-Dimethyl-1H-pyrazol-1-yl)benzonitrile is a chemical compound with a purity of 97%. It is a pyrazole derivative with a benzonitrile group, and it is commonly used in research and industrial applications. 4-(3,5-Dimethyl-1H-pyrazol-1-yl)benzonitrile 97% has a variety of potential uses, including as a building block for the synthesis of other organic compounds, as a ligand in coordination chemistry, and as a reagent in chemical reactions. It is important to handle this chemical with care, as it may have hazardous properties and should be used in a well-ventilated area with appropriate personal protective equipment.

InChI:InChI=1/C12H11N3/c1-9-7-10(2)15(14-9)12-5-3-11(8-13)4-6-12/h3-7H,1-2H3

Upstream product

• 67-51-6 3,5-dimethyl-1H-pyrazole 
• 1194-02-1 4-fluorobenzonitrile 
• 18290-96-5 3,5-dimethyl-1-(trimethylsilyl)-1H-pyrazole 
• 17672-27-4 4-hydrazinobenzonitrile 
• 126747-14-6 4-cyanophenylboronic acid 
• 123-54-6 acetylacetone 

Downstream Products

• 142161-50-0 3-[4-(3,5-Dimethyl-pyrazol-1-yl)-phenyl]-3-oxo-propionic acid ethyl ester 
• 142161-38-4 4-(2-Chloro-phenyl)-2-[4-(3,5-dimethyl-pyrazol-1-yl)-phenyl]-6-methyl-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 1607827-12-2 4-{4-[(4-bromophenyl)amino]-3,5-dimethyl-1H-pyrazol-1-yl}benzonitrile 
• 1607827-13-3 4-(3,5-dimethyl-4-morpholin-4-yl-1H-pyrazol-1-yl)benzonitrile 

Relevant articles and documents

Preparation method of pyrazole derivative

The present invention discloses a method for preparing a pyrazole derivative. The method comprises the following steps: the arylhydrazine derivative is mixed with an alkyldione derivative, reaction, to obtain a pyrazole derivative; wherein the structure of the arylhydrazine derivative is as follows: the structure of the alkyldione derivative is as follows: the structure of the pyrazole derivative provided by the present invention is green safe, simple and efficient, mild conditions, no catalyst, low cost, high synthesis efficiency. This method can synthesize a variety of 1,3,4,5-tetra-substituted pyrazole derivatives, and the method can be widely used in the field of organic synthesis.

Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS

Acid-sensing ion channels (ASICs) are a family of ion channels permeable to cations and largely responsible for the onset of acid-evoked ion currents both in neurons and in different types of cancer cells, thus representing a potential target for drug discovery. Owing to the limited attention ASIC2 has received so far, an exploratory program was initiated to identify ASIC2 inhibitors using diminazene, a known pan-ASIC inhibitor, as a chemical starting point for structural elaboration. The performed exploration enabled the identification of a novel series of ASIC2 inhibitors. In particular, compound 2u is a brain penetrant ASIC2 inhibitor endowed with an optimal pharmacokinetic profile. This compound may represent a useful tool to validate in animal models in vivo the role of ASIC2 in different neurodegenerative central nervous system pathologies.

METHOD FOR COUPLING HALOGEN-SUBSTITUTED AROMATIC COMPOUNDS WITH ORGANIC COMPOUNDS COMPRISING TRIALKYLSILYL-SUBSTITUTED HETEROATOMS

A process is provided for the preparation of aryl-heteroatom-bridged compounds by reacting a halogen-substituted aromatic compound with a trialkylsilyl-substituted heteroatom-containing organic compound.