56968-31-1

Basic information

• Product Name: 1-Piperazinepropanoic acid, 4-(2-methoxyphenyl)-, ethyl ester
• CAS NO: 56968-31-1
• Molecular Formula: C16H24N2O3
• Molecular Weight: 292.378
• Mol File: 56968-31-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-Piperazinepropanoic acid, 4-(2-methoxyphenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperazinepropanoic acid, 4-(2-methoxyphenyl)-, ethyl ester(56968-31-1)
• EPA Substance Registry System: 1-Piperazinepropanoic acid, 4-(2-methoxyphenyl)-, ethyl ester(56968-31-1)

Safety Data

• Hazardous Substances Data: 56968-31-1(Hazardous Substances Data)

Upstream product

• 539-74-2 Ethyl 3-bromopropionate 
• 5464-78-8 1-(2-methoxyphenyl)piperazine hydrochloride 
• 35386-24-4 1-(2-Methoxyphenyl)piperazine 

Downstream Products

• 732298-45-2 3-[4-(2-methoxyphenyl)-1-piperazinyl]propionic acid 
• 41103-43-9 3-[4-(2-methoxyphenyl)piperazin-1-yl]-1-propanol 
• 345222-15-3 3-[4-(2-methoxyphenyl)piperazino]propanohydrazide 
• 63854-18-2 5-hydroxy-2-{2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-ethyl}-chromen-4-one 

Relevant articles and documents

Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression

5-HT7 receptor (5-HT7R) is a promising target for the treatment of depression and neuropathic pain. 5-HT7R antagonists exhibited antidepressant effects, while the agonists produced strong anti-hyperalgesic effects. In our efforts to discover selective 5-HT 7R antagonists or agonists, N-biphenylylmethyl 2- methoxyphenylpiperazinylalkanamides 1 were designed, synthesized, and biologically evaluated against 5-HT7R. Among the synthesized compounds, N-2′-chlorobiphenylylmethyl 2- methoxyphenylpiperazinylpentanamide 1-8 showed the best binding affinity with a Ki value of 8.69 nM and it was verified as a novel antagonist according to functional assays. The compound 1-8 was very selective over 5-HT1DR, 5-HT2AR, 5-HT3R, 5-HT5AR and 5-HT6R and moderately selective over 5-HT1AR, 5-HT1BR and 5-HT2CR. The novel 5-HT7R antagonist 1-8 exhibited an antidepressant effect at a dose of 25 mg/kg in the forced swimming test in mice and showed a U-shaped dose-response curve which typically appears in 5-HT7R antagonists such as SB-269970 and lurasidone.

Novel quinazolinone derivatives as 5-HT7 receptor ligands

5-HT7 receptor antagonists generated antidepressant-like effects in animal model and the involvement of the 5-HT7 receptor in other pathophysiological mechanisms such as thermoregulation, learning and memory, and sleep has been highl

Diarylalkylpiperazines active on the lower urinary tract

Disclosed herein are novel compounds and methods for the treatment of disorders of the lower urinary tract. The novel compounds are diarylalkylpiperazine derivatives. The methods comprise the administration of the novel compounds of the invention, and other compounds that bind to 5HT1A receptors, for treating disorders of the lower urinary tract.