56973-66-1

Basic information

• Product Name: 9,9'-Di-O-(E)-feruloylsecoisolariciresil
• Synonyms: 9,9'-Di-O-(E)-feruloylsecoisolariciresil;9,9'-Di-O-(E)-feruloylsecoisolariciresinol;1,4-O-Diferuloylsecoisolariciresinol;Secoisolariciresinol diferulate
• CAS NO: 56973-66-1
• Molecular Formula: C₄₀H₄₂O₁₂
• Molecular Weight: 714.75428
• Mol File: 56973-66-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9,9'-Di-O-(E)-feruloylsecoisolariciresil(CAS DataBase Reference)
• NIST Chemistry Reference: 9,9'-Di-O-(E)-feruloylsecoisolariciresil(56973-66-1)
• EPA Substance Registry System: 9,9'-Di-O-(E)-feruloylsecoisolariciresil(56973-66-1)

Safety Data

• Hazardous Substances Data: 56973-66-1(Hazardous Substances Data)

Usage

General Description

9,9'-Di-O-(E)-feruloylsecoisolariciresinol, also known as DiFSA, is a natural phenolic compound found in various plant sources, including flaxseed and sesame seeds. It is a lignan derivative with potential antioxidant and anti-inflammatory properties. DiFSA has been studied for its potential health benefits, including its ability to protect against oxidative stress and inflammation, as well as its potential anti-cancer and neuroprotective effects. Research suggests that DiFSA may have therapeutic potential in the treatment and prevention of various diseases, making it a subject of interest for further investigation in the fields of medicine and nutrition.

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Relevant articles and documents

Synthesis and evaluation of cytotoxic effects of hanultarin and its derivatives

One of the known cytotoxic lignans is (-)-1-O-feruloyl-secoisolariciresinol designated as hanultarin, which was isolated from the seeds of Trichosanthes kirilowii. In this Letter, we described the first synthesis of 1-O-feruloyl-secoisolariciresinol, 1,4-O-diferuloyl-secoisolariceresinol and their analogues. The cytotoxicities of these compounds were evaluated against several cancer cell lines. Interestingly, we found that the feruloyl diester derivative of secoisolariciresinol was the most active cytotoxic compound against all the cancer cells tested in this experiment. The IC50 values of the1,4-O-diferuloyl-secoisolariceresinol were in the range of 7.1-9.8 lM except one cell line. In considering that both ferulic acid and secoisolariciresinol are commonly found in many plants and have no cytotoxicity, this finding is remarkable in that simple covalent bonds between the ferulic acid and secoisolariciresinol cause a cytotoxic effect.