57-39-6

Basic information

• Product Name: Tris(2-methyl-1-aziridinyl)phosphine oxide
• Synonyms: 1,1’,1’’-phosphinylidynetris(2-methyl)azridine;1,1’,1’’-phosphinylidynetris(2-methyl-Aziridine;1,1’,1’’-phosphinylidynetris[2-methyl-aziridin;c3172;ent50,003;mapo;metapoxide;metepa
• CAS NO: 57-39-6
• Molecular Formula: C₉H₁₈N₃OP
• Molecular Weight: 215.23
• EINECS: 200-326-5
• Mol File: 57-39-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 25°C
• Boiling Point: 90-92 °C (0.15-0.3 mmHg)
• Flash Point: 142.298 °C
• Appearance: /liquid
• Density: 1.0790
• PKA: 3.80±0.40(Predicted)
• CAS DataBase Reference: Tris(2-methyl-1-aziridinyl)phosphine oxide(CAS DataBase Reference)
• NIST Chemistry Reference: Tris(2-methyl-1-aziridinyl)phosphine oxide(57-39-6)
• EPA Substance Registry System: Tris(2-methyl-1-aziridinyl)phosphine oxide(57-39-6)

Safety Data

• RIDADR: 2810
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 57-39-6(Hazardous Substances Data)

Usage

Chemical Properties

Amber liquid; amine odor. Miscible with water and organic solvents.

Uses

Different sources of media describe the Uses of 57-39-6 differently. You can refer to the following data:
1. Chemosterilant; in creaseproofing and flameproofing textiles.
2. Metepa is a chemosterilant.

Hazard

Toxic by ingestion and skin absorption, strong irritant to skin.

Safety Profile

Poison by ingestion, skin contact, intraperitoneal, and subcutaneous routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic data. Animal experiments suggest cholinesterase inlubition, possibly due to metabolic products of this material in the body. When heated to decomposition it emits very toxic fumes of NOx and POx.

InChI:InChI=1/C5H10NOP/c1-4-5(2,3)6(4)8-7/h4H,1-3H3

Upstream product

• 75-55-8 2-Methylaziridine 

Relevant articles and documents

In the search for new anticancer drugs. 26. A comparison of anticancer activities of several TEPA, Thio-TEPA, Seleno-TEPA, and azetidine analogs, including congeners containing an aminoxyl moiety

A series of TEPA, Thio-TEPA, Seleno-TEPA, and azetidine analogs, including congeners containing an aminoxyl moiety, were synthesized and evaluated in vivo for anticancer activity against the murine lymphocytic leukemia P388. All aziridine derivatives were found to be active with an increase in life span ranging from 42% to 272%, and all azetidine analogs were rated as inactive with one marginal exception. An attempt was made to rationalize the results on the basis of the lipophilic properties of the compounds. The most active compound (8) possessed the most balanced lipophilic properties, corresponding to a log P value near zero.