570396-89-3

Basic information

• Product Name: 4-Pyridinecarbonitrile, 3-(1-naphthalenyl)-
• Synonyms: 4-Pyridinecarbonitrile, 3-(1-naphthalenyl)-
• CAS NO: 570396-89-3
• Molecular Formula: C16H10N2
• Molecular Weight: 0
• Mol File: 570396-89-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Pyridinecarbonitrile, 3-(1-naphthalenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinecarbonitrile, 3-(1-naphthalenyl)-(570396-89-3)
• EPA Substance Registry System: 4-Pyridinecarbonitrile, 3-(1-naphthalenyl)-(570396-89-3)

Safety Data

• Hazardous Substances Data: 570396-89-3(Hazardous Substances Data)

Upstream product

• 14906-59-3 4-cyanopyridine N-oxide 
• 13922-41-3 1-Naphthylboronic acid 
• 68325-15-5 3-chloro-isonicotinonitrile 

Downstream Products

• 570396-96-2 1-[(R)-2-Amino-3-(4-cyano-phenyl)-propionyl]-5-naphthalen-1-yl-1,2,3,6-tetrahydro-pyridine-4-carbonitrile 
• 570396-93-9 1-{[(4-cyanobenzyl)amino]acetyl}-5-(1-naphthyl)-1,2,3,6-tetrahydropyridine-4-carbonitrile 
• 570396-90-6 1-benzyl-5-(1-naphthyl)-1,2,3,6-tetrahydropyridine-4-carbonitrile 

Relevant articles and documents

Aryl tetrahydropyridine inhibitors of farnesyltransferase: Glycine, phenylalanine and histidine derivatives

Inhibitors of farnesyltransferase are effective against a variety of tumors in mouse models of cancer. Clinical trials to evaluate these agents in humans are ongoing. In our effort to develop new farnesyltransferase inhibitors, we have discovered a series of aryl tetrahydropyridines that incorporate substituted glycine, phenylalanine and histidine residues. The design, synthesis, SAR and biological properties of these compounds will be discussed.