5706-20-7

Basic information

• Product Name: 2-[4-(Dimethylamino)benzylidene]indan-1-one
• Synonyms: 2,3-Dihydro-2-[4-(dimethylamino)benzylidene]-1H-indene-1-one;2-[[4-(Dimethylamino)phenyl]methylene]-2,3-dihydro-1H-inden-1-one;2-[4-(Dimethylamino)benzylidene]indan-1-one
• CAS NO: 5706-20-7
• Molecular Formula: C₁₈H₁₇NO
• Molecular Weight: 263.33
• Mol File: 5706-20-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 456.5 °C at 760 mmHg
• Flash Point: 185.2 °C
• Appearance: /
• Density: 1.192 g/cm³
• Vapor Pressure: 1.61E-08mmHg at 25°C
• Refractive Index: 1.68
• CAS DataBase Reference: 2-[4-(Dimethylamino)benzylidene]indan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(Dimethylamino)benzylidene]indan-1-one(5706-20-7)
• EPA Substance Registry System: 2-[4-(Dimethylamino)benzylidene]indan-1-one(5706-20-7)

Safety Data

• Hazardous Substances Data: 5706-20-7(Hazardous Substances Data)

Usage

General Description

2-[4-(Dimethylamino)benzylidene]indan-1-one is an organic chemical compound with the molecular formula C20H21NO. It is a yellow crystalline powder that is insoluble in water but soluble in organic solvents. 2-[4-(Dimethylamino)benzylidene]indan-1-one is commonly used in the synthesis of various pharmaceuticals and as a reagent in chemical research. It is also known for its potential as a fluorescent probe for detecting various substances in biological and environmental samples. Additionally, 2-[4-(Dimethylamino)benzylidene]indan-1-one has been studied for its potential antimicrobial and anticancer properties. However, it is important to handle this compound with caution as it may pose health and environmental risks if not used properly.

InChI:InChI=1/C18H17NO/c1-19(2)16-9-7-13(8-10-16)11-15-12-14-5-3-4-6-17(14)18(15)20/h3-11H,12H2,1-2H3/b15-11+

Upstream product

• 83-33-0 inden-1-one 
• 100-10-7 4-dimethylamino-benzaldehyde 
• 64666-42-8 1-methyl-1-indanol 

Downstream Products

• 16307-16-7 2-(4-(dimethylamino)benzyl)-2,3-dihydro-1H-inden-1-one 
• 16307-26-9 [4-(1H-Inden-2-ylmethyl)-phenyl]-dimethyl-amine 
• 1201647-60-0 2,4-di(4-N,N-dimethylaminophenyl)spiroindan-2',3'-inden[1,2-b]-2,4-dihydrothiapyran-1'-thione 
• 1607445-90-8 7'-(4-dimethylaminophenyl)-5',6',7',7a'-tetrahydrodispiro-[indane-2,5'-pyrrolo[1,2-c][1,3]thiazole-6',2-indan]-1,3,1-trione 
• 61926-46-3 2-(5-dimethylamino-thiophen-2-ylmethylene)-indane-1,3-dione 
• 5402-87-9 C₁₈H₂₁NO 

Relevant articles and documents

Diversified Photo/Electronic Functions Based on a Simple Chalcone Skeleton: Effects of Substitution Pattern and Molecular Packing

Structurally simple chalcone derivatives 1–2 are prepared and their diversified emission behaviors are deeply investigated. Two polymorphs (1G: λem = 536 nm, Φf = 0.08, τ = 1.81 ns; 1O: λem = 573 nm, Φf = 0.19,

In vitro Anti-Trypanosomal Activities of Indanone-Based Chalcones

Human African trypanosomiasis is a neglected infectious disease that affects mostly people living in the rural areas of Africa. Current treatment options are limited to just four drugs that have been in use of four to nine decades. The life-threatening to

2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase

In the present study, a series of twenty-two 2-benzylidene-1-indanone derivatives were synthesised and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The 2-benzylidene-1-indanone derivatives are structurally related to a series of benzylideneindanone derivatives which has previously been found to be MAO-B inhibitors. This study finds that the 2-benzylidene-1-indanones are MAO-B specific inhibitors with IC50values 50?50?=?0.131?μM). An analysis of the structure–activity relationships for MAO-B inhibition show that substitution on the A-ring with a 5-hydroxy group and on the B-ring with halogens and the methyl group yield high potency inhibition. It may therefore be concluded that 2-benzylidene-1-indanone analogues are promising leads for design of therapies for disorders such as Parkinson's disease.