5706-81-0

Basic information

• Product Name: Hydrazinecarbothioamide, 2-[(2-methylphenyl)methylene]-
• CAS NO: 5706-81-0
• Molecular Formula: C9H11N3S
• Molecular Weight: 193.272
• Mol File: 5706-81-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Hydrazinecarbothioamide, 2-[(2-methylphenyl)methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarbothioamide, 2-[(2-methylphenyl)methylene]-(5706-81-0)
• EPA Substance Registry System: Hydrazinecarbothioamide, 2-[(2-methylphenyl)methylene]-(5706-81-0)

Safety Data

• Hazardous Substances Data: 5706-81-0(Hazardous Substances Data)

Upstream product

• 4346-94-5 thiosemicarbazide hydrochloride 
• 529-20-4 2-methylphenyl aldehyde 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 59565-54-7 5-(2-methylphenyl)-1,3,4-thiadiazol-2-amine 
• 1383954-93-5 [Pt(CH₃C₆H₃CHN₂C(S)NH₂)(CH₂(P(C₆H₅)2)2)] 
• 1383954-69-5 [Pt(CH₃C₆H₃CHN₂C(S)NH₂)(P(C₆H₅)3)] 
• 1011943-68-2 1-(2-methylbenzylidene)-2-[4-(4-fluorophenyl)thiazol-2-yl]hydrazine 
• 1011946-35-2 1-(2-methylbenzylidene)-2-[4-(4-chlorophenyl)thiazol-2-yl]hydrazine 
• 101446-81-5 2-methyl-benzaldehyde [4-(2,4-dichloro-phenyl)-5-oxo-thiazolidin-2-ylidene]-hydrazone 
• 101602-14-6 2-methyl-benzaldehyde [4-(4-bromo-phenyl)-5-oxo-thiazolidin-2-ylidene]-hydrazone 
• 108896-99-7 2-methyl-benzaldehyde [5-(4-chloro-phenyl)-4-oxo-thiazolidin-2-ylidene]-hydrazone 
• 100950-10-5 2-methyl-benzaldehyde (5-butyl-4-oxo-thiazolidin-2-ylidene)-hydrazone 
• 100719-87-7 2-methyl-benzaldehyde (4-oxo-5-propyl-thiazolidin-2-ylidene)-hydrazone 

Relevant articles and documents

PhI-Catalyzed Intramolecular Oxidative Coupling Toward Synthesis of 2-Amino-1,3,4-Thiadizoles

A highly efficient method for the synthesis of thiadiazole derivatives via intramolecular oxidative coupling of thiosemicarbazide, using the in situ generated hypervalent iodine(III) reagents is developed. The protocol can be carried out smoothly and provides a variety of thiadiazole derivatives in moderate to excellent yields. Graphical Abstract: A highly efficient method for the synthesis of thiadiazole derivatives via PhI-catalyzed intramolecular oxidative coupling of thiosemicarbazide has been developed.

Thiosemicarbazone platinacycles with tertiary phosphines. Preparation of novel heterodinuclear platinum-tungsten complexes

Treatment of thiosemicarbazones (R1C6H 4)C(H)NN(H)C(S)NHR2 [R1,R2: 4-Me,H (a); 4-Me,Me (b); 4-Me,Et (c); 2-Me,H (d); 2-Me,Me (e); 2-Me,Et (f)] with cis-[PtMe2(cod)] afforded the

Structural characteristics of thiosemicarbazones as inhibitors of melanogenesis

A series of thiosemicarbazones 2(e-s) have been synthesized and studied their structure-activity relationship as melanogenesis inhibitor. Among them, (Z)-2-(naphthalen-1-ylmethylene)hydrazinecarbothioamide (2q, >100% inhibition at 10 μM, IC50 = 1.1 μM, C log P = 3.039) showed the strongest inhibitory activity. Regarding their structure-activity relationship, the hydrophobic substituents regardless the position on phenyl ring of benzaldehyde thiosemicarbazones enhance the inhibitory activity. Furthermore, the aromatic group of benzaldehydethiosemicarbazones can be replaced with sterically bulky cyclohexyl. Thus, hydrophobicity of the aryl or alkyl group on hydrazine of thiosemicarbazones is determinant factor for their inhibitory activity in melanogenesis rather than planarity.