57081-29-5

Basic information

• Product Name: ethyl [4-(4-chlorobenzyl)phenoxy]acetate
• CAS NO: 57081-29-5
• Molecular Formula: C₁₇H₁₇ClO₃
• Molecular Weight: 304.7681
• Mol File: 57081-29-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 408.4°C at 760 mmHg
• Flash Point: 152.2°C
• Density: 1.182g/cm³
• Vapor Pressure: 7.03E-07mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: ethyl [4-(4-chlorobenzyl)phenoxy]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl [4-(4-chlorobenzyl)phenoxy]acetate(57081-29-5)
• EPA Substance Registry System: ethyl [4-(4-chlorobenzyl)phenoxy]acetate(57081-29-5)

Safety Data

• Hazardous Substances Data: 57081-29-5(Hazardous Substances Data)

Upstream product

• 52890-73-0 4-(4-chloro-benzyl)-phenol 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 57081-28-4 4-(4'-chlorobenzyl)-phenoxy acetic acid 
• 70930-63-1 2-[4-(4-Chloro-benzyl)-phenoxy]-ethanol 
• 71654-76-7 [4-(4-Chloro-benzyl)-phenoxy]-acetic acid 2-(benzyl-methyl-amino)-ethyl ester 
• 71548-27-1 2-{2-[4-(4-Chloro-benzyl)-phenoxy]-acetoxy}-benzoic acid methyl ester 
• 70930-68-6 2-Acetoxy-benzoic acid 2-[4-(4-chloro-benzyl)-phenoxy]-ethyl ester 
• 57081-30-8 [4-(4-Chloro-benzyl)-phenoxy]-acetic acid cyclopentyl ester 
• 81126-95-6 [4-(4-Chloro-benzyl)-phenoxy]-acetic acid 2-dimethylamino-ethyl ester 

Relevant articles and documents

Cholesterol-lowering phenoxyalkanoic acid esters

Compounds possessing pharmaceutical activity as substances able to lower the level of fatty substances in the blood possess the following general formula: STR1 wherein R represents hydrogen, halogen, hydroxy or alkyl or alkoxy containing from 1 to 4 carbon atoms; A1 and A2 which can be the same or different are hydrogen or alkyl containing from 1 to 9 carbon atoms such that A1 and A2 contain together not more than 10 carbon atoms, Y is oxygen, in which case X is benzyl, benzyloxy or benzylthio or benzyl, benzyloxy or benzylthio substituted by R and Z is amine, azacyclohydrocarbyloxy cycloalkoxy containing from 3 to 6 ring carbon atoms or tertiary aminoalkoxy or pivaloyloxyalkoxy in which the alkoxy group contains from 1 to 3 carbon atoms, or X is hydrogen and Z is pivaloyloxyalkoxy in which the alkoxy group contains from 1 to 3 carbon atoms, or Y is oxygen, X is benzyl, benzyloxy or benzylthio or benzyl, benzyloxy or benzylthio substituted by R and Z is alkoxy containing from 1 to 4 carbon atoms, hydroxy or O- M+, M being a metal cation of Main Groups I, II or III of the Periodic System of the Elements or an organic base cation or ammonium ion, A1 and A2 being the same and being as aforesaid or being different with one of A1 and A2 being hydrogen or both being hydrogen and X being a para substituent with respect to Y in the benzene ring in the same general formula, Y is oxygen, X is hydrogen and Z is amine, azacyclohydrocarbyloxy or pivaloyloxyalkoxy in which the alkoxy group contains from 1 to 3 carbon atoms, Or Y is sulphur, in which case X is hydrogen, benzyl, benzyloxy or benzylthio or benzyl, benzyloxy or benzylthio substituted by R and Z is amine, azacyclohydrocarbyloxy, alkoxy containing from 1 to 4 carbon atoms, hydroxy, O- M+ wherein M is a metal cation of Main Groups I, II or III of the Periodic System of The Elements or an organic base cation or ammonium ion, cycloalkoxy containing from 3 to 6 ring carbon atoms or tertiaryaminoalkoxy, pivaloyloxyalkoxy or pyridyl-C-alkoxy in which the alkoxy group contains from 1 to 3 carbon atoms, and pharmacologically acceptable acid addition and quaternary ammonium salts of compounds containing basic groups, and optical isomers of said compounds when A1 and A2 are different.