571-39-1

Basic information

• Product Name: 1-ANDROSTENEDIONE
• Synonyms: 1-ANDROSTENEDIONE;(5R,8R,9S,10R,13S,14S)-10,13-dimethyl-5,6,7,8,9,11,12,14,15,16-decahydro-4H-cyclopenta[a]phenanthrene-3,17-dione
• CAS NO: 571-39-1
• Molecular Formula: C₁₉H₂₆O₂
• Molecular Weight: 286.40854
• Mol File: 571-39-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 171-172 °C(Solv: ethanol (64-17-5))
• Boiling Point: 418.8±45.0 °C(Predicted)
• Appearance: /
• Density: 1.099±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-ANDROSTENEDIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ANDROSTENEDIONE(571-39-1)
• EPA Substance Registry System: 1-ANDROSTENEDIONE(571-39-1)

Safety Data

• Hazardous Substances Data: 571-39-1(Hazardous Substances Data)

Usage

Uses

5β-Androst-1-ene-3,17-dione is an anabolic andorgenic steroid metabolite of designer steroid found in human urine.

Upstream product

• 846-46-8 (5ξ)-androstane-3,17-dione 
• 846-46-8 (5ξ)-androstane-3,17-dione 
• 1229-12-5 androstane-3,17-dione 
• 897-06-3 Androsta-1,4-diene-3,17-dione 

Relevant articles and documents

Steroidal isomers with uniform mass spectra of their per-TMS derivatives: Synthesis of 17-hydroxyandrostan-3-ones, androst-1-, and -4-ene-3,17-diols

In human sports doping control analysis most of the steroids are analyzed after enzymatic hydrolysis of the glucuronides as per-trimethylsilyl (TMS) derivatives applying gas chromatography-mass spectrometry (GC-MS). According to the recommendations of the World Anti-Doping Agency the identification of analytes should be based on retention time and on mass spectrometric characterization. This study shows that the bis-TMS derivatives of 16 specific C19 steroids, namely the stereoisomers of 5ξ-androst-1-ene-3ξ,17ξ-diol (8 isomers), androst-4-ene-3ξ,17ξ-diol (4 isomers), and 17ξ-hydroxy-5ξ-androstan-3-one (4 isomers), reveal very similar mass spectra. As a rule, when taking the retention times, which are provided as Kovac indices for all these isomers, into account, a restriction to two or three possible isomers is possible. Reliable identification should additionally include a comparison of the retention times of the analytes with the reference compounds measured concomitantly. In some cases standard addition may be appropriate. Due to the limited availability, the above mentioned isomers were synthesized by reduction of the corresponding α,β-unsaturated oxo steroids either with K-Selectride or by catalytic hydrogenation (Pd/C as catalyst). The products of the reactions were identified by means of nuclear magnetic resonance (NMR) characterization and by further reduction to the corresponding 5ξ-androstane-3ξ,17ξ-diols and GC-MS comparison with commercially available reference standards.

Modulation of the reactivity profile of IBX by ligand complexation: Ambient temperature dehydrogenation of aldehydes and ketones to α,β-unsaturated carbonyl compounds

The reactivity profile of IBX can be altered by complexation with various ligands (e. g. 1-4). A new complex, IBX·MPO, is a remarkably effective oxidant and allows the room-temperature dehydrogenation of carbonyl compounds, for example, the formation of cyclooctenones 6 and 7 from cyclooctanone 5. IBX = iodoxybenzoic acid; MPO = 4-methoxypyridine-N-oxide.

Purification and mechanism of action of a steroid delta-4-5-beta-dehydrogenase.

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