5711-61-5

Basic information

• Product Name: 2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-OXADIAZOLE
• Synonyms: BUTTPARK 154\17-91;ART-CHEM-BB B014637;2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-OXADIAZOLE;AKOS B014637;5-(4-METHOXYPHENYL)-1,3,4-OXADIAZOL-2-AMINE;TIMTEC-BB SBB000297;2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-OXADI&;2-Amino-5-(4-methoxyphenyl)-1,3,4-oxadiazole 97%
• CAS NO: 5711-61-5
• Molecular Formula: C₉H₉N₃O₂
• Molecular Weight: 191.19
• Product Categories: Amines;Oxadiazoles & Thiadiazoles;Oxadiazoles & Thiadiazoles;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Oxadiazoles
• Mol File: 5711-61-5.mol
• Article Data: 39

Chemical Properties

• Melting Point: 245-249℃
• Boiling Point: 368 °C at 760 mmHg
• Flash Point: 176.3 °C
• Appearance: /
• Density: 1.272g/cm³
• Vapor Pressure: 1.31E-05mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-OXADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-OXADIAZOLE(5711-61-5)
• EPA Substance Registry System: 2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-OXADIAZOLE(5711-61-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 5711-61-5(Hazardous Substances Data)

Usage

General Description

2-Amino-5-(4-methoxyphenyl)-1,3,4-oxadiazole, also known as 4-Methoxyphenyl-5-amino-1,3,4-oxadiazole, is a chemical compound with the molecular formula C9H9N3O2. It is a heterocyclic organic compound that contains both nitrogen and oxygen atoms in its structure. 2-AMINO-5-(4-METHOXYPHENYL)-1,3,4-OXADIAZOLE has potential medicinal properties and is being studied for its potential use in pharmaceuticals, particularly in the area of cancer research. It has also been investigated for its antibacterial and antifungal properties. The presence of the oxadiazole ring in its structure gives this compound potential for diverse biological activities and pharmaceutical applications. Further research is being conducted to explore its therapeutic potential and applications in various fields.

InChI:InChI=1/C9H9N3O2/c1-13-7-4-2-6(3-5-7)8-11-12-9(10)14-8/h2-5H,1H3,(H2,10,12)

Upstream product

• 412314-08-0 1-(4-methoxy-benzoyl)-S-methyl-iso thiosemicarbazide 
• 833-84-1 1-(4-methoxy-benzoyl)-thiosemicarbazide 
• 6292-71-3 4-methoxybenzaldehyde semicarbazone 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 23275-52-7 5-(4-methoxy-phenyl)-[1,2,4]oxadiazol-3-ylamine 
• 199339-16-7 2-[(Z)-5-(4-Methoxy-phenyl)-[1,3,4]oxadiazol-2-ylimino]-5-methyl-thiazolidin-4-one 
• 199339-10-1 2-[(Z)-5-(4-Methoxy-phenyl)-[1,3,4]oxadiazol-2-ylimino]-5-phenyl-thiazolidin-4-one 
• 100-07-2 4-methoxy-benzoyl chloride 
• 123-11-5 4-methoxy-benzaldehyde 
• 4426-72-6 hydrazine carboxamide 
• 100-09-4 4-methoxybenzoic acid 
• 506-68-3 bromocyane 
• 563-41-7 semicarbazide hydrochloride 

Downstream Products

• 32333-05-4 furfurylidene-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-amine 
• 67454-92-6 [5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-ylamino]-methanol 
• 13751-22-9 1-(4-Methoxy-benzoyl)-5-carbamoyl-diamino-guanidin 
• 60988-23-0 1-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-3-p-tolyl-thiourea 
• 53297-64-6 6-(4-chloro-phenyl)-2-(4-methoxy-phenyl)-[1,3,4]oxadiazolo[3,2-a][1,3,5]triazine-5,7-dione 
• 32333-03-2 benzylidene-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-amine 
• 32333-04-3 (4-methoxy-benzylidene)-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-amine 
• 60988-15-0 1-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-3-phenyl-thiourea 
• 59940-09-9 2-chloro-N-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]acetamide 
• 34254-10-9 3-chloroacetyl-5-(4-methoxy-phenyl)-3H-[1,3,4]oxadiazol-2-ylideneamine 
• 32405-32-6 [5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-(3-phenyl-allylidene)-amine 
• 51324-01-7 2-(4-methoxy-phenyl)-5-oxo-5H-[1,3,4]oxadiazolo[3,2-a]pyrimidine-7-carboxylic acid methyl ester 
• 34257-02-8 3-(3-chloro-propionyl)-5-(4-methoxy-phenyl)-3H-[1,3,4]oxadiazol-2-ylideneamine 
• 60988-20-7 1-(2-ethoxy-phenyl)-3-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-thiourea 

Relevant articles and documents

Synthesis and anticonvulsant evaluation of indoline derivatives of functionalized aryloxadiazole amine and benzothiazole acetamide

A series of N-(substituted benzothiazole-2-yl)-2-(2,3-dioxoindolin-1-yl)acetamide (4a-i) and substituted-[3-((5-phenyl-1,3,4-oxadiazole-2-yl)imino)indolene-2-one] (5a-f) were designed, synthesized fulfilling the structural requirement of pharmacophore and evaluated for anticonvulsant activities using maximal electroshock test (MES), subcutaneous pentylenetetrazole (scPTZ) seizures and neurotoxicity by motor impairment model in mice. The most active compoundN-(5-chlorobenzo[d]thiazol-2-yl)-2-(2,3-dioxoindolin-1-yl)acetamide (4a) has shown significant anticonvulsant activity against both MES and scPTZ screens and emerged as most effective anticonvulsant compound with median dose of 35.7 mg/kg (MES ED50), 88.15 mg/kg (scPTZ ED50) and toxic dose (TD50) was found to be > 500mg/kg. In silico studies including molecular docking study was carried to establish the molecular interaction of potent compound (4a) in both Na+ channel and GABAA receptors. The prediction of pharmacokinetic parameters and distance mapping of compounds were also performed to establish the drug likeness property.

SSAO INHIBITOR

The present invention provides an SSAO inhibitor and an application thereof in preparing a drug for treating a disease related to SSAO. In particular, the present invention provides a compound shown in formula (IV) and a pharmaceutically acceptable salt thereof.

Synthesis of N-pyrimidin[1,3,4]oxadiazoles and N-pyrimidin[1,3,4]-thiadiazoles from 1,3,4-oxadiazol-2-amines and 1,3,4-thiadiazol-2-amines via Pd-catalyzed heteroarylamination

An efficient and practical procedure was developed to prepare various N-pyrimidin[1,3,4]oxadiazole and thiadiazole scaffolds using a Buchwald-type coupling. The products of this reaction are otherwise difficult to access and could be used as building bloc