57159-62-3 Usage
Description
N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE, also known as 3-(2-bromoacetamido)propanoic acid NHS ester, is a PEG linker containing a bromide group and an NHS ester. It is a white solid with a hydrophilic PEG spacer that increases solubility in aqueous media. The bromide (Br) acts as a very good leaving group for nucleophilic substitution reactions, while the NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The spacer arm of this compound is 6.2 Angstroms.
Uses
Used in Biochemistry and Molecular Biology:
N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE is used as a sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent for the covalent attachment of proteins, oligonucleotides, and other amine-containing molecules. This application is due to its ability to form stable covalent bonds with primary amines through the NHS ester and with sulfhydryl groups through the bromoacetamido moiety.
Used in Drug Development and Pharmaceutical Industry:
N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE is used as a key component in the synthesis of drug conjugates and targeted therapeutics. The reason for this application is its reactivity with both amine and sulfhydryl groups, allowing for the specific and stable attachment of therapeutic agents to biomolecules, such as antibodies or peptides, for targeted drug delivery.
Used in Diagnostics and Imaging:
N-SUCCINIMIDYL 3-(BROMOACETAMIDO)PROPIONATE is used as a labeling agent for the modification of biomolecules, such as proteins or oligonucleotides, to enhance their detection in diagnostic assays or imaging techniques. The application is based on the compound's ability to form stable covalent bonds with primary amines, allowing for the attachment of detection tags or imaging agents to the biomolecules of interest.
Check Digit Verification of cas no
The CAS Registry Mumber 57159-62-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,7,1,5 and 9 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 57159-62:
(7*5)+(6*7)+(5*1)+(4*5)+(3*9)+(2*6)+(1*2)=143
143 % 10 = 3
So 57159-62-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H11BrN2O5/c10-5-6(13)11-4-3-9(16)17-12-7(14)1-2-8(12)15/h1-5H2,(H,11,13)
57159-62-3Relevant articles and documents
ANTIMICROBIAL VACCINE COMPOSITIONS
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Paragraph 0078, (2021/03/05)
This invention is directed to antimicrobial vaccine compounds and compositions comprising oligosaccharide β-(1→6)- glucosamine groups having from 3 to 12 glucosamine units linked through a linker group to tetanus toxoid wherein the toxoid is primarily in
New heterobifunctional cross-linking reagents for protein conjugation, N-(bromoacetamido-n-alkanoyloxy)succinimides.
Zaitsu,Ohnishi,Hosoya,Sugimoto,Ohkura
, p. 1991 - 1997 (2007/10/02)
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